Impact of genetic notification on smoking cessation: systematic review and pooled-analysis.
OBJECTIVES: This study aimed to evaluate the impact of genetic notification of smoking-related disease risk on smoking cessation in the general population. Secondary objectives were to assess the impact of genetic notification on intention-to-quit smoking and on emotional outcomes as well as the und...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3394798?pdf=render |
| _version_ | 1811218773378596864 |
|---|---|
| author | Sylviane de Viron Johan Van der Heyden Elena Ambrosino Marc Arbyn Angela Brand Herman Van Oyen |
| author_facet | Sylviane de Viron Johan Van der Heyden Elena Ambrosino Marc Arbyn Angela Brand Herman Van Oyen |
| author_sort | Sylviane de Viron |
| collection | DOAJ |
| description | OBJECTIVES: This study aimed to evaluate the impact of genetic notification of smoking-related disease risk on smoking cessation in the general population. Secondary objectives were to assess the impact of genetic notification on intention-to-quit smoking and on emotional outcomes as well as the understanding and the recall of this notification. METHODS: A systematic review of articles from inception to August 2011 without language restriction was realized using PubMed, Embase, Scopus, Web of Science, PsycINFO and Toxnet. Other publications were identified using hand search. The pooled-analysis included only randomized trials. Comparison groups were (i) high and low genetic risk versus control, and (ii) high versus low genetic risk. For the pooled-analysis random effect models were applied and sensitivity analyses were conducted. RESULTS: Eight papers from seven different studies met the inclusion criteria of the review. High genetic risk notification was associated with short-term increased depression and anxiety. Four randomized studies were included in the pooled-analysis, which revealed a significant impact of genetic notification on smoking cessation in comparison to controls (clinical risk notification or no intervention) in short term follow-up less than 6 months (RR = 1.55, 95% CI 1.09-2.21). CONCLUSIONS: In short term follow-up, genetic notification increased smoking cessation in comparison to control interventions. However, there is no evidence of long term effect (up to 12 month) on smoking cessation. Further research is needed to assess more in depth how genetic notification of smoking-related disease could contribute to smoking cessation. |
| first_indexed | 2024-04-12T07:15:01Z |
| format | Article |
| id | doaj.art-5e5d6fc8e2bb4896b833f2a2d806273b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T07:15:01Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5e5d6fc8e2bb4896b833f2a2d806273b2022-12-22T03:42:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4023010.1371/journal.pone.0040230Impact of genetic notification on smoking cessation: systematic review and pooled-analysis.Sylviane de VironJohan Van der HeydenElena AmbrosinoMarc ArbynAngela BrandHerman Van OyenOBJECTIVES: This study aimed to evaluate the impact of genetic notification of smoking-related disease risk on smoking cessation in the general population. Secondary objectives were to assess the impact of genetic notification on intention-to-quit smoking and on emotional outcomes as well as the understanding and the recall of this notification. METHODS: A systematic review of articles from inception to August 2011 without language restriction was realized using PubMed, Embase, Scopus, Web of Science, PsycINFO and Toxnet. Other publications were identified using hand search. The pooled-analysis included only randomized trials. Comparison groups were (i) high and low genetic risk versus control, and (ii) high versus low genetic risk. For the pooled-analysis random effect models were applied and sensitivity analyses were conducted. RESULTS: Eight papers from seven different studies met the inclusion criteria of the review. High genetic risk notification was associated with short-term increased depression and anxiety. Four randomized studies were included in the pooled-analysis, which revealed a significant impact of genetic notification on smoking cessation in comparison to controls (clinical risk notification or no intervention) in short term follow-up less than 6 months (RR = 1.55, 95% CI 1.09-2.21). CONCLUSIONS: In short term follow-up, genetic notification increased smoking cessation in comparison to control interventions. However, there is no evidence of long term effect (up to 12 month) on smoking cessation. Further research is needed to assess more in depth how genetic notification of smoking-related disease could contribute to smoking cessation.http://europepmc.org/articles/PMC3394798?pdf=render |
| spellingShingle | Sylviane de Viron Johan Van der Heyden Elena Ambrosino Marc Arbyn Angela Brand Herman Van Oyen Impact of genetic notification on smoking cessation: systematic review and pooled-analysis. PLoS ONE |
| title | Impact of genetic notification on smoking cessation: systematic review and pooled-analysis. |
| title_full | Impact of genetic notification on smoking cessation: systematic review and pooled-analysis. |
| title_fullStr | Impact of genetic notification on smoking cessation: systematic review and pooled-analysis. |
| title_full_unstemmed | Impact of genetic notification on smoking cessation: systematic review and pooled-analysis. |
| title_short | Impact of genetic notification on smoking cessation: systematic review and pooled-analysis. |
| title_sort | impact of genetic notification on smoking cessation systematic review and pooled analysis |
| url | http://europepmc.org/articles/PMC3394798?pdf=render |
| work_keys_str_mv | AT sylvianedeviron impactofgeneticnotificationonsmokingcessationsystematicreviewandpooledanalysis AT johanvanderheyden impactofgeneticnotificationonsmokingcessationsystematicreviewandpooledanalysis AT elenaambrosino impactofgeneticnotificationonsmokingcessationsystematicreviewandpooledanalysis AT marcarbyn impactofgeneticnotificationonsmokingcessationsystematicreviewandpooledanalysis AT angelabrand impactofgeneticnotificationonsmokingcessationsystematicreviewandpooledanalysis AT hermanvanoyen impactofgeneticnotificationonsmokingcessationsystematicreviewandpooledanalysis |