Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature
AimTo describe the currently available evidence regarding the efficacy and safety of preoperative tumor marking using indocyanine green (ICG) prior to laparoscopic or robotic colorectal resections.MethodsA systematic search for relevant studies was conducted using the following databases: Embase (OV...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1258343/full |
| _version_ | 1797744470556409856 |
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| author | Michael K. Konstantinidis Michael K. Konstantinidis Argyrios Ioannidis Panteleimon Vassiliu Nikolaos Arkadopoulos Ioannis S. Papanikolaou Konstantinos Stavridis Gaetano Gallo Dimitrios Karagiannis Manish Chand Steven D. Wexner Konstantinos Konstantinidis |
| author_facet | Michael K. Konstantinidis Michael K. Konstantinidis Argyrios Ioannidis Panteleimon Vassiliu Nikolaos Arkadopoulos Ioannis S. Papanikolaou Konstantinos Stavridis Gaetano Gallo Dimitrios Karagiannis Manish Chand Steven D. Wexner Konstantinos Konstantinidis |
| author_sort | Michael K. Konstantinidis |
| collection | DOAJ |
| description | AimTo describe the currently available evidence regarding the efficacy and safety of preoperative tumor marking using indocyanine green (ICG) prior to laparoscopic or robotic colorectal resections.MethodsA systematic search for relevant studies was conducted using the following databases: Embase (OVID), MEDLINE® (OVID), APA PsycInfo (OVID), Global Health (OVID) and HMIC Health Management Information Consortium (OVID) through June 2022 reported according to PRISMA 2020 guidelines. Primary outcome was the detection rate of the tumor sites preoperatively marked with ICG. Secondary outcomes were timing of ICG injection in days prior to the operation and technique-related complications.ResultsEight single center studies, published between 2008 and 2022, were identified yielding a total of 1,061 patients, of whom 696 were preoperatively tattooed with ICG. Injection dosage of diluted ICG ranged from 0.1–1.5 ml. Four studies used the saline test injection method prior to ICG injection. When the marking was placed within one week, the visualization rate was 650/668 (97%), whereas when it was longer than one week, the detection rate was 8/56 (14%). No severe complications were reported.ConclusionPreoperative tumor marking using ICG prior to minimally invasive colorectal resections is safe and effective, allowing intraoperative tumor site location when performed up to a week prior to surgery without disturbing the surgical view in potential mild complications. |
| first_indexed | 2024-03-12T15:10:08Z |
| format | Article |
| id | doaj.art-5e64947701c74c1a9addcf48a1c2234d |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-03-12T15:10:08Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-5e64947701c74c1a9addcf48a1c2234d2023-08-11T17:49:03ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-08-011010.3389/fsurg.2023.12583431258343Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literatureMichael K. Konstantinidis0Michael K. Konstantinidis1Argyrios Ioannidis2Panteleimon Vassiliu3Nikolaos Arkadopoulos4Ioannis S. Papanikolaou5Konstantinos Stavridis6Gaetano Gallo7Dimitrios Karagiannis8Manish Chand9Steven D. Wexner10Konstantinos Konstantinidis11Department of General, Laparoscopic, Oncologic and Robotic Surgery, Athens Medical Center, Athens, GreeceFourth Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceDepartment of General, Laparoscopic, Oncologic and Robotic Surgery, Athens Medical Center, Athens, GreeceFourth Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceFourth Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceHepatogastroenterology Unit, Second Department of Internal Medicine—Propaedeutic, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece2nd Department of Obstetrics and Gynaecology, Aretaieion Hospital, University of Athens, Athens, GreeceDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Gastroenterology and Hepatology, Athens Medical Center, Athens, GreeceUCL Division of Surgery and Interventional Sciences, WEISS Centre, University College London, London, United KingdomDepartment of Colorectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, United StatesDepartment of General, Laparoscopic, Oncologic and Robotic Surgery, Athens Medical Center, Athens, GreeceAimTo describe the currently available evidence regarding the efficacy and safety of preoperative tumor marking using indocyanine green (ICG) prior to laparoscopic or robotic colorectal resections.MethodsA systematic search for relevant studies was conducted using the following databases: Embase (OVID), MEDLINE® (OVID), APA PsycInfo (OVID), Global Health (OVID) and HMIC Health Management Information Consortium (OVID) through June 2022 reported according to PRISMA 2020 guidelines. Primary outcome was the detection rate of the tumor sites preoperatively marked with ICG. Secondary outcomes were timing of ICG injection in days prior to the operation and technique-related complications.ResultsEight single center studies, published between 2008 and 2022, were identified yielding a total of 1,061 patients, of whom 696 were preoperatively tattooed with ICG. Injection dosage of diluted ICG ranged from 0.1–1.5 ml. Four studies used the saline test injection method prior to ICG injection. When the marking was placed within one week, the visualization rate was 650/668 (97%), whereas when it was longer than one week, the detection rate was 8/56 (14%). No severe complications were reported.ConclusionPreoperative tumor marking using ICG prior to minimally invasive colorectal resections is safe and effective, allowing intraoperative tumor site location when performed up to a week prior to surgery without disturbing the surgical view in potential mild complications.https://www.frontiersin.org/articles/10.3389/fsurg.2023.1258343/fullfluorescence imagingindocyanine greencolorectal surgerycolorectal cancercolorectal tumorpreoperative tumor marking |
| spellingShingle | Michael K. Konstantinidis Michael K. Konstantinidis Argyrios Ioannidis Panteleimon Vassiliu Nikolaos Arkadopoulos Ioannis S. Papanikolaou Konstantinos Stavridis Gaetano Gallo Dimitrios Karagiannis Manish Chand Steven D. Wexner Konstantinos Konstantinidis Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature Frontiers in Surgery fluorescence imaging indocyanine green colorectal surgery colorectal cancer colorectal tumor preoperative tumor marking |
| title | Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature |
| title_full | Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature |
| title_fullStr | Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature |
| title_full_unstemmed | Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature |
| title_short | Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature |
| title_sort | preoperative tumor marking with indocyanine green icg prior to minimally invasive colorectal cancer a systematic review of current literature |
| topic | fluorescence imaging indocyanine green colorectal surgery colorectal cancer colorectal tumor preoperative tumor marking |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1258343/full |
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