Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China
We performed this study to clarify the dynamic changes in maternal manganese (Mn) concentration during pregnancy and its association with spontaneous preterm birth (SPB). A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2018 to 2020. Singleton pregnancy w...
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/6/1413 |
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| author | Weiling Han Wei Zheng Aili Wang Junxi Chen Jia Wang Junhua Huang Hang An Yuru Ma Kexin Zhang Ruihua Yang Lailai Yan Zhiwen Li Guanghui Li |
| author_facet | Weiling Han Wei Zheng Aili Wang Junxi Chen Jia Wang Junhua Huang Hang An Yuru Ma Kexin Zhang Ruihua Yang Lailai Yan Zhiwen Li Guanghui Li |
| author_sort | Weiling Han |
| collection | DOAJ |
| description | We performed this study to clarify the dynamic changes in maternal manganese (Mn) concentration during pregnancy and its association with spontaneous preterm birth (SPB). A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2018 to 2020. Singleton pregnancy women aged 18–44 (<i>n</i> = 488) were involved in the study, including 244 cases of SPB and 244 controls. All of the participants provided blood samples twice (in their first and third trimesters). Inductively coupled plasma mass spectrometry (ICP-MS) was used for the laboratory analysis, and unconditional logistic regression was used for the statistical analysis. We found that the maternal Mn levels were significantly higher in the third trimester than those in the first trimester (median: 1.23 vs. 0.81 ng/mL). The SPB risk was increased to 1.65 (95% CI: 1.04–2.62, <i>p</i> = 0.035) in the highest Mn level (third tertile) in the third trimester, especially in normal-weight women (OR: 2.07, 95% CI: 1.18–3.61, <i>p</i> = 0.011) or non-premature rupture of membrane (PROM) women (OR: 3.93, 95% CI: 2.00–7.74, <i>p</i> < 0.001). Moreover, a dose-dependent relationship exists between the SPB risk and maternal Mn concentration in non-PROM women (P trend < 0.001). In conclusion, dynamic monitoring of maternal Mn level during pregnancy would be helpful for SPB prevention, especially in normal-weight and non-PROM women. |
| first_indexed | 2024-03-11T06:04:09Z |
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| language | English |
| last_indexed | 2024-03-11T06:04:09Z |
| publishDate | 2023-03-01 |
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| series | Nutrients |
| spelling | doaj.art-5e654c04433d495388db8308423e67952023-11-17T13:05:27ZengMDPI AGNutrients2072-66432023-03-01156141310.3390/nu15061413Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in ChinaWeiling Han0Wei Zheng1Aili Wang2Junxi Chen3Jia Wang4Junhua Huang5Hang An6Yuru Ma7Kexin Zhang8Ruihua Yang9Lailai Yan10Zhiwen Li11Guanghui Li12Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaInstitute of Reproductive and Child Health, Peking University, Beijing 100191, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaInstitute of Reproductive and Child Health, Peking University, Beijing 100191, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, ChinaInstitute of Reproductive and Child Health, Peking University, Beijing 100191, ChinaDivision of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaWe performed this study to clarify the dynamic changes in maternal manganese (Mn) concentration during pregnancy and its association with spontaneous preterm birth (SPB). A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2018 to 2020. Singleton pregnancy women aged 18–44 (<i>n</i> = 488) were involved in the study, including 244 cases of SPB and 244 controls. All of the participants provided blood samples twice (in their first and third trimesters). Inductively coupled plasma mass spectrometry (ICP-MS) was used for the laboratory analysis, and unconditional logistic regression was used for the statistical analysis. We found that the maternal Mn levels were significantly higher in the third trimester than those in the first trimester (median: 1.23 vs. 0.81 ng/mL). The SPB risk was increased to 1.65 (95% CI: 1.04–2.62, <i>p</i> = 0.035) in the highest Mn level (third tertile) in the third trimester, especially in normal-weight women (OR: 2.07, 95% CI: 1.18–3.61, <i>p</i> = 0.011) or non-premature rupture of membrane (PROM) women (OR: 3.93, 95% CI: 2.00–7.74, <i>p</i> < 0.001). Moreover, a dose-dependent relationship exists between the SPB risk and maternal Mn concentration in non-PROM women (P trend < 0.001). In conclusion, dynamic monitoring of maternal Mn level during pregnancy would be helpful for SPB prevention, especially in normal-weight and non-PROM women.https://www.mdpi.com/2072-6643/15/6/1413manganesespontaneous preterm birthrepeated measurementdynamic monitoring |
| spellingShingle | Weiling Han Wei Zheng Aili Wang Junxi Chen Jia Wang Junhua Huang Hang An Yuru Ma Kexin Zhang Ruihua Yang Lailai Yan Zhiwen Li Guanghui Li Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China Nutrients manganese spontaneous preterm birth repeated measurement dynamic monitoring |
| title | Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China |
| title_full | Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China |
| title_fullStr | Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China |
| title_full_unstemmed | Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China |
| title_short | Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China |
| title_sort | association of maternal plasma manganese with the risk of spontaneous preterm birth a nested case control study based on the beijing birth cohort study bbcs in china |
| topic | manganese spontaneous preterm birth repeated measurement dynamic monitoring |
| url | https://www.mdpi.com/2072-6643/15/6/1413 |
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