EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMA
Objective: To investigate the effect of unilateral intravitreal Bevacizumab on contralateral eye in bilateral diabetic macular edema. Study Design: Quasi-experimental study. Place and Duration of Study: Retina Department of Al-Shifa Trust Eye Hospital, Rawalpindi, from Sep to Dec 2020. Meth...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2021-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/5853/3735 |
| _version_ | 1818941189148114944 |
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| author | Aziz Jan Bashir Abdul Hannan Salman Sohail Chaudhary Sarah Zafar Abdullah Naeem Syed Syed Hassan Massana |
| author_facet | Aziz Jan Bashir Abdul Hannan Salman Sohail Chaudhary Sarah Zafar Abdullah Naeem Syed Syed Hassan Massana |
| author_sort | Aziz Jan Bashir |
| collection | DOAJ |
| description | Objective: To investigate the effect of unilateral intravitreal Bevacizumab on contralateral eye in bilateral diabetic macular edema.
Study Design: Quasi-experimental study.
Place and Duration of Study: Retina Department of Al-Shifa Trust Eye Hospital, Rawalpindi, from Sep to Dec 2020.
Methodology: Thirty-two patients were enrolled with consecutive sampling. All the patients had clinically diagnosed diabetic macular edema having >275µm macular thickness on OCT. They were injected with 1.25mg/0.05mL of Bevacizumab in one eye. Baseline macular thickness was compared with 4 weeks follow up macular thickness, using Optical Coherence Tomography.
Results: The central macular thickness in the untreated eye at baseline was 396.97 ± 29.79 µm and 388.34 ± 30.06 µm at 4 weeks (p-value=0.001). The difference in central macular thickness in treated and untreated eyes were 28.44 ± 4.11 µm and 19.81 ± 5.31 µm respectively (p-value = 0.001). There were statistically significant differences between these measurements.
Conclusion: Injecting Bevacizumab in one eye for diabetic macular edema has statistically significant effect on the contralateral non-injected eye macular thickness. |
| first_indexed | 2024-12-20T06:51:35Z |
| format | Article |
| id | doaj.art-5e66f3e1c19a4b33893e905f759ef447 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-20T06:51:35Z |
| publishDate | 2021-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-5e66f3e1c19a4b33893e905f759ef4472022-12-21T19:49:32ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422021-12-0171620752077EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMAAziz Jan Bashir0Abdul Hannan1Salman Sohail Chaudhary2Sarah Zafar3Abdullah Naeem Syed4Syed Hassan Massana5Al-Shifa Trust Eye Hospital, Rawalpindi PakistanAl-Shifa Trust Eye Hospital, Rawalpindi PakistanAl-Shifa Trust Eye Hospital, Rawalpindi PakistanAl-Shifa Trust Eye Hospital, Rawalpindi PakistanAl-Shifa Trust Eye Hospital, Rawalpindi PakistanAl-Shifa Trust Eye Hospital, Rawalpindi PakistanObjective: To investigate the effect of unilateral intravitreal Bevacizumab on contralateral eye in bilateral diabetic macular edema. Study Design: Quasi-experimental study. Place and Duration of Study: Retina Department of Al-Shifa Trust Eye Hospital, Rawalpindi, from Sep to Dec 2020. Methodology: Thirty-two patients were enrolled with consecutive sampling. All the patients had clinically diagnosed diabetic macular edema having >275µm macular thickness on OCT. They were injected with 1.25mg/0.05mL of Bevacizumab in one eye. Baseline macular thickness was compared with 4 weeks follow up macular thickness, using Optical Coherence Tomography. Results: The central macular thickness in the untreated eye at baseline was 396.97 ± 29.79 µm and 388.34 ± 30.06 µm at 4 weeks (p-value=0.001). The difference in central macular thickness in treated and untreated eyes were 28.44 ± 4.11 µm and 19.81 ± 5.31 µm respectively (p-value = 0.001). There were statistically significant differences between these measurements. Conclusion: Injecting Bevacizumab in one eye for diabetic macular edema has statistically significant effect on the contralateral non-injected eye macular thickness.https://www.pafmj.org/index.php/PAFMJ/article/view/5853/3735bevacizumabcentral retinal thicknessdiabetic macular edema |
| spellingShingle | Aziz Jan Bashir Abdul Hannan Salman Sohail Chaudhary Sarah Zafar Abdullah Naeem Syed Syed Hassan Massana EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMA Pakistan Armed Forces Medical Journal bevacizumab central retinal thickness diabetic macular edema |
| title | EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMA |
| title_full | EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMA |
| title_fullStr | EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMA |
| title_full_unstemmed | EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMA |
| title_short | EFFECTS OF UNILATERAL INTRAVITREAL BEVACIZUMAB ON THE CONTRALATERAL EYE HAVING DIABETIC MACULAR EDEMA |
| title_sort | effects of unilateral intravitreal bevacizumab on the contralateral eye having diabetic macular edema |
| topic | bevacizumab central retinal thickness diabetic macular edema |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/5853/3735 |
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