Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules?
<i>Background and objectives:</i> Thyroid nodules are a common finding in clinical practice and can be either benign or malignant. The aim of this study was to compare laboratory parameters between patients with malignant thyroid nodules and those with benign thyroid nodules. <i>Ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/8/1488 |
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| author | Mervat Matei Mihaela Maria Vlad Ioana Golu Cristina Ștefania Dumitru Graziano De Scisciolo Sergiu-Ciprian Matei |
| author_facet | Mervat Matei Mihaela Maria Vlad Ioana Golu Cristina Ștefania Dumitru Graziano De Scisciolo Sergiu-Ciprian Matei |
| author_sort | Mervat Matei |
| collection | DOAJ |
| description | <i>Background and objectives:</i> Thyroid nodules are a common finding in clinical practice and can be either benign or malignant. The aim of this study was to compare laboratory parameters between patients with malignant thyroid nodules and those with benign thyroid nodules. <i>Materials and methods:</i> A total of 845 patients were included, with 251 in the study group (malignant thyroid nodules) and 594 in the control group (benign thyroid nodules). <i>Results:</i> Our results show that there were statistically significant differences in several laboratory parameters, including FT3, FT4, ESR, fibrinogen, WBC, and lymphocyte percentage, between the two patient groups (<i>p</i> < 0.05). <i>Conclusions:</i> These findings suggest that certain laboratory parameters may be useful in differentiating between benign and malignant thyroid nodules and could aid in the diagnosis and treatment of thyroid cancer. However, further diagnostic tests such as fine-needle aspiration biopsy and imaging studies are typically required for an accurate diagnosis. Routine laboratory tests prove most effective when combined with other diagnostic methods to identify thyroid cancer. Although not conclusive on their own, these tests significantly suggest and guide physicians to suspect malignancy in thyroid nodules. This affirmative answer to our question, “Can routine laboratory tests be suggestive in determining suspicions of malignancy in the case of thyroid nodules?” aligns with the results of our study. |
| first_indexed | 2024-03-10T23:45:33Z |
| format | Article |
| id | doaj.art-5e66fe6c7201489f933634562dee76ec |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T23:45:33Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-5e66fe6c7201489f933634562dee76ec2023-11-19T02:07:07ZengMDPI AGMedicina1010-660X1648-91442023-08-01598148810.3390/medicina59081488Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules?Mervat Matei0Mihaela Maria Vlad1Ioana Golu2Cristina Ștefania Dumitru3Graziano De Scisciolo4Sergiu-Ciprian Matei5Department of Doctoral Studies, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Sq. no. 2, 300041 Timișoara, RomaniaEndocrinology Clinic, “Pius Brînzeu” Emergency Clinical Hospital Timișoara, Liviu Rebreanu Boulevard no. 156, 300723 Timișoara, RomaniaEndocrinology Clinic, “Pius Brînzeu” Emergency Clinical Hospital Timișoara, Liviu Rebreanu Boulevard no. 156, 300723 Timișoara, RomaniaDepartment of Microscopic Morphology/Histology, Angiogenesis Research Center, “Victor Babeș” University of Medicine and Pharmacy, Sq. Eftimie Murgu no. 2, 300041 Timișoara, RomaniaFaculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Sq. no. 2, 300041 Timișoara, RomaniaAbdominal Surgery and Phlebology Research Center, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timișoara, Romania<i>Background and objectives:</i> Thyroid nodules are a common finding in clinical practice and can be either benign or malignant. The aim of this study was to compare laboratory parameters between patients with malignant thyroid nodules and those with benign thyroid nodules. <i>Materials and methods:</i> A total of 845 patients were included, with 251 in the study group (malignant thyroid nodules) and 594 in the control group (benign thyroid nodules). <i>Results:</i> Our results show that there were statistically significant differences in several laboratory parameters, including FT3, FT4, ESR, fibrinogen, WBC, and lymphocyte percentage, between the two patient groups (<i>p</i> < 0.05). <i>Conclusions:</i> These findings suggest that certain laboratory parameters may be useful in differentiating between benign and malignant thyroid nodules and could aid in the diagnosis and treatment of thyroid cancer. However, further diagnostic tests such as fine-needle aspiration biopsy and imaging studies are typically required for an accurate diagnosis. Routine laboratory tests prove most effective when combined with other diagnostic methods to identify thyroid cancer. Although not conclusive on their own, these tests significantly suggest and guide physicians to suspect malignancy in thyroid nodules. This affirmative answer to our question, “Can routine laboratory tests be suggestive in determining suspicions of malignancy in the case of thyroid nodules?” aligns with the results of our study.https://www.mdpi.com/1648-9144/59/8/1488thyroid nodulesthyroid cancerlaboratory testsusual analysis |
| spellingShingle | Mervat Matei Mihaela Maria Vlad Ioana Golu Cristina Ștefania Dumitru Graziano De Scisciolo Sergiu-Ciprian Matei Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? Medicina thyroid nodules thyroid cancer laboratory tests usual analysis |
| title | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
| title_full | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
| title_fullStr | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
| title_full_unstemmed | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
| title_short | Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules? |
| title_sort | can routine laboratory tests be suggestive in determining suspicions of malignancy in the case of thyroid nodules |
| topic | thyroid nodules thyroid cancer laboratory tests usual analysis |
| url | https://www.mdpi.com/1648-9144/59/8/1488 |
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