Sex Differences in Vestibular Schwannoma
Vestibular schwannoma (VS) are equally common in men and woman. A number of epidemiological studies have reported on sex-specific aspects of incidence, tumor size, tinnitus and hearing loss. However, data on sex-specific, pre- and post-surgically quality of life (QoL) are rare. The objective of the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/17/4365 |
| _version_ | 1797582732617842688 |
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| author | Kathrin Machetanz Sophie S. Wang Linda Oberle Marcos Tatagiba Georgios Naros |
| author_facet | Kathrin Machetanz Sophie S. Wang Linda Oberle Marcos Tatagiba Georgios Naros |
| author_sort | Kathrin Machetanz |
| collection | DOAJ |
| description | Vestibular schwannoma (VS) are equally common in men and woman. A number of epidemiological studies have reported on sex-specific aspects of incidence, tumor size, tinnitus and hearing loss. However, data on sex-specific, pre- and post-surgically quality of life (QoL) are rare. The objective of the present study was to determine sex-specific aspects on QoL in VS. Health-related QoL was analyzed in 260 patients (112 male/148 female) with unilateral sporadic VS using general (SF-36: general Short-Form Health Survey), disease-specific (PANQOL: Penn Acoustic Neuroma Quality-of-Life Scale, PANQOL) and symptom-specific (DHI: Dizziness Handicap Inventory; HHI: Hearing Handicap Inventory; THI: Tinnitus Handicap Inventory; FDI: Facial Disability Index) QoL questionnaires. Sex differences were evaluated pre- and postoperative by multi- and univariate analyses based on 200 preoperative and 88 postoperative questionnaires. Female patients were significantly more affected by dizziness, headaches, reduced energy and anxiety. Energy and balance changed similarly in both sexes after surgery. However, postoperative women tended to be more affected by facial palsy and headaches than men. Despite the greater physical impairment, general health improved equivalently or even more in female patients than in males. In conclusion, self-rated QoL in VS is significantly affected by sex and surgery. This should be taken into account when counseling VS patients regarding observation, radiotherapy, and surgery. |
| first_indexed | 2024-03-10T23:26:42Z |
| format | Article |
| id | doaj.art-5e68ec0c6d1d481ca68319c9ce519c90 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T23:26:42Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5e68ec0c6d1d481ca68319c9ce519c902023-11-19T07:56:46ZengMDPI AGCancers2072-66942023-09-011517436510.3390/cancers15174365Sex Differences in Vestibular SchwannomaKathrin Machetanz0Sophie S. Wang1Linda Oberle2Marcos Tatagiba3Georgios Naros4Department of Neurosurgery and Neurotechnology, Eberhard Karls University, 72074 Tuebingen, GermanyDepartment of Neurosurgery and Neurotechnology, Eberhard Karls University, 72074 Tuebingen, GermanyDepartment of Neurosurgery and Neurotechnology, Eberhard Karls University, 72074 Tuebingen, GermanyDepartment of Neurosurgery and Neurotechnology, Eberhard Karls University, 72074 Tuebingen, GermanyDepartment of Neurosurgery and Neurotechnology, Eberhard Karls University, 72074 Tuebingen, GermanyVestibular schwannoma (VS) are equally common in men and woman. A number of epidemiological studies have reported on sex-specific aspects of incidence, tumor size, tinnitus and hearing loss. However, data on sex-specific, pre- and post-surgically quality of life (QoL) are rare. The objective of the present study was to determine sex-specific aspects on QoL in VS. Health-related QoL was analyzed in 260 patients (112 male/148 female) with unilateral sporadic VS using general (SF-36: general Short-Form Health Survey), disease-specific (PANQOL: Penn Acoustic Neuroma Quality-of-Life Scale, PANQOL) and symptom-specific (DHI: Dizziness Handicap Inventory; HHI: Hearing Handicap Inventory; THI: Tinnitus Handicap Inventory; FDI: Facial Disability Index) QoL questionnaires. Sex differences were evaluated pre- and postoperative by multi- and univariate analyses based on 200 preoperative and 88 postoperative questionnaires. Female patients were significantly more affected by dizziness, headaches, reduced energy and anxiety. Energy and balance changed similarly in both sexes after surgery. However, postoperative women tended to be more affected by facial palsy and headaches than men. Despite the greater physical impairment, general health improved equivalently or even more in female patients than in males. In conclusion, self-rated QoL in VS is significantly affected by sex and surgery. This should be taken into account when counseling VS patients regarding observation, radiotherapy, and surgery.https://www.mdpi.com/2072-6694/15/17/4365facial palsygender medicinemicrosurgical resectionquality of lifesexvestibular schwannoma |
| spellingShingle | Kathrin Machetanz Sophie S. Wang Linda Oberle Marcos Tatagiba Georgios Naros Sex Differences in Vestibular Schwannoma Cancers facial palsy gender medicine microsurgical resection quality of life sex vestibular schwannoma |
| title | Sex Differences in Vestibular Schwannoma |
| title_full | Sex Differences in Vestibular Schwannoma |
| title_fullStr | Sex Differences in Vestibular Schwannoma |
| title_full_unstemmed | Sex Differences in Vestibular Schwannoma |
| title_short | Sex Differences in Vestibular Schwannoma |
| title_sort | sex differences in vestibular schwannoma |
| topic | facial palsy gender medicine microsurgical resection quality of life sex vestibular schwannoma |
| url | https://www.mdpi.com/2072-6694/15/17/4365 |
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