Evidence of Polyphenols Efficacy against Dry Eye Disease
Dry eye disease is a multifactorial pathology compromising the quality of life of patients, resulting in significant damage of the ocular surface and discomfort. The current therapeutical strategies are not able to definitively resolve the underlying causes and stop the symptoms. Polyphenols are pro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/2/190 |
| _version_ | 1797406165392424960 |
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| author | Gaia Favero Enrico Moretti Kristína Krajčíková Vladimíra Tomečková Rita Rezzani |
| author_facet | Gaia Favero Enrico Moretti Kristína Krajčíková Vladimíra Tomečková Rita Rezzani |
| author_sort | Gaia Favero |
| collection | DOAJ |
| description | Dry eye disease is a multifactorial pathology compromising the quality of life of patients, resulting in significant damage of the ocular surface and discomfort. The current therapeutical strategies are not able to definitively resolve the underlying causes and stop the symptoms. Polyphenols are promising natural molecules that are receiving increasing attention for their activity/effects in counteracting the main pathologic mechanisms of dry eye disease and reducing its symptoms. In the present review, a deep literature search focusing on the main polyphenols tested against dry eye disease was conducted, analyzing related in vitro, in vivo, and clinical studies to provide a comprehensive and current review on the state of the art. Polyphenols present multiple effects against dry eye diseases-related ocular surface injury. In particular, the observed beneficial effects of polyphenols on corneal cells are the reduction of the pathological processes of inflammation, oxidative stress, and apoptosis and modulation of the tear film. Due to numerous studies reporting that polyphenols are effective and safe for treating the pathological mechanisms of this ocular surface disease, we believe that future studies should confirm and extend the evidence of polyphenols efficacy in clinical practice against dry eye disease and help to develop new ophthalmic drug(s). |
| first_indexed | 2024-03-09T03:22:27Z |
| format | Article |
| id | doaj.art-5e6a95d6aad74efc9dbd13d38b923441 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T03:22:27Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-5e6a95d6aad74efc9dbd13d38b9234412023-12-03T15:07:50ZengMDPI AGAntioxidants2076-39212021-01-0110219010.3390/antiox10020190Evidence of Polyphenols Efficacy against Dry Eye DiseaseGaia Favero0Enrico Moretti1Kristína Krajčíková2Vladimíra Tomečková3Rita Rezzani4Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, ItalyAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, ItalyDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University, 040 12 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University, 040 12 Košice, SlovakiaAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, ItalyDry eye disease is a multifactorial pathology compromising the quality of life of patients, resulting in significant damage of the ocular surface and discomfort. The current therapeutical strategies are not able to definitively resolve the underlying causes and stop the symptoms. Polyphenols are promising natural molecules that are receiving increasing attention for their activity/effects in counteracting the main pathologic mechanisms of dry eye disease and reducing its symptoms. In the present review, a deep literature search focusing on the main polyphenols tested against dry eye disease was conducted, analyzing related in vitro, in vivo, and clinical studies to provide a comprehensive and current review on the state of the art. Polyphenols present multiple effects against dry eye diseases-related ocular surface injury. In particular, the observed beneficial effects of polyphenols on corneal cells are the reduction of the pathological processes of inflammation, oxidative stress, and apoptosis and modulation of the tear film. Due to numerous studies reporting that polyphenols are effective and safe for treating the pathological mechanisms of this ocular surface disease, we believe that future studies should confirm and extend the evidence of polyphenols efficacy in clinical practice against dry eye disease and help to develop new ophthalmic drug(s).https://www.mdpi.com/2076-3921/10/2/190antioxidantsdry eye diseaseepithelial corneal cellsinflammationpolyphenols |
| spellingShingle | Gaia Favero Enrico Moretti Kristína Krajčíková Vladimíra Tomečková Rita Rezzani Evidence of Polyphenols Efficacy against Dry Eye Disease Antioxidants antioxidants dry eye disease epithelial corneal cells inflammation polyphenols |
| title | Evidence of Polyphenols Efficacy against Dry Eye Disease |
| title_full | Evidence of Polyphenols Efficacy against Dry Eye Disease |
| title_fullStr | Evidence of Polyphenols Efficacy against Dry Eye Disease |
| title_full_unstemmed | Evidence of Polyphenols Efficacy against Dry Eye Disease |
| title_short | Evidence of Polyphenols Efficacy against Dry Eye Disease |
| title_sort | evidence of polyphenols efficacy against dry eye disease |
| topic | antioxidants dry eye disease epithelial corneal cells inflammation polyphenols |
| url | https://www.mdpi.com/2076-3921/10/2/190 |
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