Human Milk Oligosaccharide 2′-Fucosyllactose Inhibits Ligand Binding to C-Type Lectin DC-SIGN but Not to Langerin

Human Milk Oligosaccharide 2′-Fucosyllactose Inhibits Ligand Binding to C-Type Lectin DC-SIGN but Not to Langerin

Human milk oligosaccharides (HMOs) and their most abundant component, 2′-Fucosyllactose (2′-FL), are known to be immunomodulatory. Previously, it was shown that HMOs and 2′-FL bind to the C-type lectin receptor DC-SIGN. Here we show, using a ligand-receptor competition assay, that a whole mixture of...

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Bibliographic Details
Main Authors: Reshmi Mukherjee, Victor J. Somovilla, Fabrizio Chiodo, Sven Bruijns, Roland J. Pieters, Johan Garssen, Yvette van Kooyk, Aletta D. Kraneveld, Jeroen van Bergenhenegouwen
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
DC-SIGN
2′-FL
human milk oligosaccharides
langerin
lewis B antigen
Online Access:https://www.mdpi.com/1422-0067/23/23/14745

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