Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis
Aim: Wound healing is a complex phenomenon with various biological changes in tissue integrity, low-level laser therapy (LLLT) has acquired several unique components to help into accelerating tissue reconstruction and eventually wound healing. Thus, in the present systematic review and meta-analysis...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2022-10-01
|
| Series: | Exploration of Medicine |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/em/Article/1001106 |
| _version_ | 1828100332658360320 |
|---|---|
| author | Seyyed Amir Seyyedi Saman Taram Mohammad Heydari Rohollah Valizadeh |
| author_facet | Seyyed Amir Seyyedi Saman Taram Mohammad Heydari Rohollah Valizadeh |
| author_sort | Seyyed Amir Seyyedi |
| collection | DOAJ |
| description | Aim: Wound healing is a complex phenomenon with various biological changes in tissue integrity, low-level laser therapy (LLLT) has acquired several unique components to help into accelerating tissue reconstruction and eventually wound healing. Thus, in the present systematic review and meta-analysis study, the role of LLLT in oral mucosal wound healing following surgical interventions was investigated.
Methods: The study databases, including PubMed, Web of Knowledge, Google Scholar, Scopus, and Cochrane, were searched by two blinded investigators considering eligible studies based on the following keywords: “Wound Healing”, “Oral Mucosal Wound Healing”, “Laser therapy”, “Low-level laser therapy”, “Oral Surgery”, “Photobiomodulation therapy”, among 88 screened, only 12 articles were eligible for the final analysis.
Results: There was a significant difference between control and laser group in all mentioned studies in the case of wound epithelialization in gingiva, with weighted mean difference (MD) of –0.28, [95% confidence interval (CI): –0.37, –0.19, P < 0.001], periodontium 1 day postoperative, with weighted MD of –0.56 (95% CI: –0.84, –0.27, P < 0.001) and 7 days postoperative, with weighted MD of –0.73 (95% CI: –0.97, –0.49, P < 0.001). In the cases of postoperative pain, LLLT has significantly declined pain in comparison with control group with weighted MD of –0.47 (95% CI: –0.69, –0.24, P < 0.001) for 7 days postoperative and –0.55 (95% CI: –0.96, –0.13, P = 0.005) 14 days postoperatively.
Conclusions: LLLT can be used as a promising tool in oral surgeries because of its inevitable capability in accelerating wound healing and reducing intraoperative pain. |
| first_indexed | 2024-04-11T08:26:42Z |
| format | Article |
| id | doaj.art-5e6cf8e07935459d90d19370266f71fb |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-04-11T08:26:42Z |
| publishDate | 2022-10-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-5e6cf8e07935459d90d19370266f71fb2022-12-22T04:34:41ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062022-10-013545146010.37349/emed.2022.00106Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysisSeyyed Amir Seyyedi0https://orcid.org/0000-0003-0039-3855Saman Taram1https://orcid.org/0000-0002-6112-4782Mohammad Heydari2https://orcid.org/0000-0001-7955-9891Rohollah Valizadeh3https://orcid.org/0000-0002-6913-3210Dental Faculty, Urmia University of Medical Sciences, Urmia 5714783734, IranDental Faculty, Urmia University of Medical Sciences, Urmia 5714783734, IranDepartment of Epidemiology, Medical Faculty, Urmia University of Medical Sciences, Urmia 5714783734, IranDepartment of Biostatistics and Epidemiology, School of Medicine, Urmia University of Medical Sciences, Urmia 5714783734, IranAim: Wound healing is a complex phenomenon with various biological changes in tissue integrity, low-level laser therapy (LLLT) has acquired several unique components to help into accelerating tissue reconstruction and eventually wound healing. Thus, in the present systematic review and meta-analysis study, the role of LLLT in oral mucosal wound healing following surgical interventions was investigated. Methods: The study databases, including PubMed, Web of Knowledge, Google Scholar, Scopus, and Cochrane, were searched by two blinded investigators considering eligible studies based on the following keywords: “Wound Healing”, “Oral Mucosal Wound Healing”, “Laser therapy”, “Low-level laser therapy”, “Oral Surgery”, “Photobiomodulation therapy”, among 88 screened, only 12 articles were eligible for the final analysis. Results: There was a significant difference between control and laser group in all mentioned studies in the case of wound epithelialization in gingiva, with weighted mean difference (MD) of –0.28, [95% confidence interval (CI): –0.37, –0.19, P < 0.001], periodontium 1 day postoperative, with weighted MD of –0.56 (95% CI: –0.84, –0.27, P < 0.001) and 7 days postoperative, with weighted MD of –0.73 (95% CI: –0.97, –0.49, P < 0.001). In the cases of postoperative pain, LLLT has significantly declined pain in comparison with control group with weighted MD of –0.47 (95% CI: –0.69, –0.24, P < 0.001) for 7 days postoperative and –0.55 (95% CI: –0.96, –0.13, P = 0.005) 14 days postoperatively. Conclusions: LLLT can be used as a promising tool in oral surgeries because of its inevitable capability in accelerating wound healing and reducing intraoperative pain.https://www.explorationpub.com/Journals/em/Article/1001106low-level laser therapyoral mucosal wound healingoral surgery |
| spellingShingle | Seyyed Amir Seyyedi Saman Taram Mohammad Heydari Rohollah Valizadeh Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis Exploration of Medicine low-level laser therapy oral mucosal wound healing oral surgery |
| title | Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis |
| title_full | Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis |
| title_fullStr | Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis |
| title_short | Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis |
| title_sort | efficacy of low level laser therapy in oral mucosal surgical wound healing a systematic review and meta analysis |
| topic | low-level laser therapy oral mucosal wound healing oral surgery |
| url | https://www.explorationpub.com/Journals/em/Article/1001106 |
| work_keys_str_mv | AT seyyedamirseyyedi efficacyoflowlevellasertherapyinoralmucosalsurgicalwoundhealingasystematicreviewandmetaanalysis AT samantaram efficacyoflowlevellasertherapyinoralmucosalsurgicalwoundhealingasystematicreviewandmetaanalysis AT mohammadheydari efficacyoflowlevellasertherapyinoralmucosalsurgicalwoundhealingasystematicreviewandmetaanalysis AT rohollahvalizadeh efficacyoflowlevellasertherapyinoralmucosalsurgicalwoundhealingasystematicreviewandmetaanalysis |