Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-ph...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/23/5601 |
| _version_ | 1827701183998853120 |
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| author | Carissa M. Lloyd Neil Colgin Steven L. Cobb |
| author_facet | Carissa M. Lloyd Neil Colgin Steven L. Cobb |
| author_sort | Carissa M. Lloyd |
| collection | DOAJ |
| description | Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry. |
| first_indexed | 2024-03-10T14:29:07Z |
| format | Article |
| id | doaj.art-5e6d4fed10d4435d9bb32893221ea94d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:29:07Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5e6d4fed10d4435d9bb32893221ea94d2023-11-20T22:45:33ZengMDPI AGMolecules1420-30492020-11-012523560110.3390/molecules25235601Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their ApplicationsCarissa M. Lloyd0Neil Colgin1Steven L. Cobb2Department of Chemistry, Faculty of Science, Durham University, Durham DH1 3LE, UKCambridge Research Biochemicals, 17-18 Belasis Court, Belasis Hall Technology Park, Billingham, Cleveland TS23 4AZ, UKDepartment of Chemistry, Faculty of Science, Durham University, Durham DH1 3LE, UKPeptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry.https://www.mdpi.com/1420-3049/25/23/5601peptidefluoromethyl ketonepeptide synthesispeptide modificationfluorinetherapeutic |
| spellingShingle | Carissa M. Lloyd Neil Colgin Steven L. Cobb Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications Molecules peptide fluoromethyl ketone peptide synthesis peptide modification fluorine therapeutic |
| title | Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications |
| title_full | Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications |
| title_fullStr | Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications |
| title_full_unstemmed | Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications |
| title_short | Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications |
| title_sort | current synthetic routes to peptidyl mono fluoromethyl ketones fmks and their applications |
| topic | peptide fluoromethyl ketone peptide synthesis peptide modification fluorine therapeutic |
| url | https://www.mdpi.com/1420-3049/25/23/5601 |
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