Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities
Sphingosine 1-Phosphate (S1P) is a bioactive lipid intermediate in the sphingolipid metabolism, which exist in two pools, intracellular and extracellular, and each pool has a different function. The circulating extracellular pool, specifically the plasma S1P is shown to be important in regulating va...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00353/full |
| _version_ | 1818453419309924352 |
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| author | Gunanidhi Dhangadamajhi Shailja Singh |
| author_facet | Gunanidhi Dhangadamajhi Shailja Singh |
| author_sort | Gunanidhi Dhangadamajhi |
| collection | DOAJ |
| description | Sphingosine 1-Phosphate (S1P) is a bioactive lipid intermediate in the sphingolipid metabolism, which exist in two pools, intracellular and extracellular, and each pool has a different function. The circulating extracellular pool, specifically the plasma S1P is shown to be important in regulating various physiological processes related to malaria pathogenesis in recent years. Although blood cells (red blood cells and platelets), vascular endothelial cells and hepatocytes are considered as the important sources of plasma S1P, their extent of contribution is still debated. The red blood cells (RBCs) and platelets serve as a major repository of intracellular S1P due to lack, or low activity of S1P degrading enzymes, however, contribution of platelets toward maintaining plasma S1P is shown negligible under normal condition. Substantial evidences suggest platelets loss during falciparum infection as a contributing factor for severe malaria. However, platelets function as a source for plasma S1P in malaria needs to be examined experimentally. RBC being the preferential site for parasite seclusion, and having the ability of trans-cellular S1P transportation to EC upon tight cell-cell contact, might play critical role in differential S1P distribution and parasite growth. In the present review, we have summarized the significance of both the S1P pools in the context of malaria, and how the RBC content of S1P can be channelized in better ways for its possible implication in therapeutic opportunities to control malaria. |
| first_indexed | 2024-12-14T21:38:41Z |
| format | Article |
| id | doaj.art-5e6de25ecb7e4779b8af42a153bcc752 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-14T21:38:41Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-5e6de25ecb7e4779b8af42a153bcc7522022-12-21T22:46:32ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-08-011010.3389/fcimb.2020.00353543927Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic OpportunitiesGunanidhi Dhangadamajhi0Shailja Singh1Department of Biotechnology, North Orissa University, Baripada, IndiaSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, IndiaSphingosine 1-Phosphate (S1P) is a bioactive lipid intermediate in the sphingolipid metabolism, which exist in two pools, intracellular and extracellular, and each pool has a different function. The circulating extracellular pool, specifically the plasma S1P is shown to be important in regulating various physiological processes related to malaria pathogenesis in recent years. Although blood cells (red blood cells and platelets), vascular endothelial cells and hepatocytes are considered as the important sources of plasma S1P, their extent of contribution is still debated. The red blood cells (RBCs) and platelets serve as a major repository of intracellular S1P due to lack, or low activity of S1P degrading enzymes, however, contribution of platelets toward maintaining plasma S1P is shown negligible under normal condition. Substantial evidences suggest platelets loss during falciparum infection as a contributing factor for severe malaria. However, platelets function as a source for plasma S1P in malaria needs to be examined experimentally. RBC being the preferential site for parasite seclusion, and having the ability of trans-cellular S1P transportation to EC upon tight cell-cell contact, might play critical role in differential S1P distribution and parasite growth. In the present review, we have summarized the significance of both the S1P pools in the context of malaria, and how the RBC content of S1P can be channelized in better ways for its possible implication in therapeutic opportunities to control malaria.https://www.frontiersin.org/article/10.3389/fcimb.2020.00353/fullsphingosine 1-phosphatemalariaRBCrosettetherapeutic |
| spellingShingle | Gunanidhi Dhangadamajhi Shailja Singh Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities Frontiers in Cellular and Infection Microbiology sphingosine 1-phosphate malaria RBC rosette therapeutic |
| title | Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities |
| title_full | Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities |
| title_fullStr | Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities |
| title_full_unstemmed | Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities |
| title_short | Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities |
| title_sort | sphingosine 1 phosphate in malaria pathogenesis and its implication in therapeutic opportunities |
| topic | sphingosine 1-phosphate malaria RBC rosette therapeutic |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.00353/full |
| work_keys_str_mv | AT gunanidhidhangadamajhi sphingosine1phosphateinmalariapathogenesisanditsimplicationintherapeuticopportunities AT shailjasingh sphingosine1phosphateinmalariapathogenesisanditsimplicationintherapeuticopportunities |