FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
FKRP mutations cause muscular dystrophies with varied clinical presentations. The target of FKRP is α-dystroglycan, but here the authors show that FKRP also directs sialylation of fibronectin, a process that is essential for recruitment o collagen to the muscle basement membrane.
Bibliographic Details
| Main Authors: |
A. J. Wood,
C. H. Lin,
M. Li,
K. Nishtala,
S. Alaei,
F. Rossello,
C. Sonntag,
L. Hersey,
L. B. Miles,
C. Krisp,
S. Dudczig,
A. J. Fulcher,
S. Gibertini,
P. J. Conroy,
A. Siegel,
M. Mora,
P. Jusuf,
N. H. Packer,
P. D. Currie |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23217-6
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