Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats
A high intake of sugar-sweetened fruity beverage (FB) is associated with a higher risk of metabolic syndromes, but the health outcome of 100% fruit juice (FJ) intake remains unclear. We aim to reveal health outcomes of diet intervention (FJ or FB) with system profiling via interaction of gut microbi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Food Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927123000229 |
| _version_ | 1797798005202485248 |
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| author | Kewen Wang Yang Zhao Lei Xu Xiaojun Liao Zhenzhen Xu |
| author_facet | Kewen Wang Yang Zhao Lei Xu Xiaojun Liao Zhenzhen Xu |
| author_sort | Kewen Wang |
| collection | DOAJ |
| description | A high intake of sugar-sweetened fruity beverage (FB) is associated with a higher risk of metabolic syndromes, but the health outcome of 100% fruit juice (FJ) intake remains unclear. We aim to reveal health outcomes of diet intervention (FJ or FB) with system profiling via interaction of gut microbiota and metabolomics in a rat (Rattus norvegicus) model. Firstly, the glucose, sucrose, fructose, and bioactive metabolites of FJ and FB were analyzed, and FJ possessed higher sucrose and flavonoids, while FB showed higher glucose and fructose. Secondly, C0 was set as the control group on Day 0, and a 4-week diet invention was performed to control, FJ-intake, and FB-intake groups with normal saline, FJ, and FB, respectively. The results showed that FJ improved alpha diversity and decreased the Firmicutes/Bacteroidota ratio (F/B ratio) of gut microbiota and prevented insulin resistance. However, FB possessed unchanged microbial diversity and enhanced F/B ratio, causing insulin resistance with renal triglyceride accumulation. In summary, FJ, although naturally containing similar amounts of total free sugars as FB, could be a healthier drink choice. |
| first_indexed | 2024-03-13T03:56:55Z |
| format | Article |
| id | doaj.art-5e70fccdacea4814b2c662179f0ef8a0 |
| institution | Directory Open Access Journal |
| issn | 2665-9271 |
| language | English |
| last_indexed | 2024-03-13T03:56:55Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj.art-5e70fccdacea4814b2c662179f0ef8a02023-06-22T05:04:57ZengElsevierCurrent Research in Food Science2665-92712023-01-016100454Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in ratsKewen Wang0Yang Zhao1Lei Xu2Xiaojun Liao3Zhenzhen Xu4College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China; Institute of Quality Standard & Testing Technology for Agro-Products, Key Laboratory of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing, 100081, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China; Institute of Quality Standard & Testing Technology for Agro-Products, Key Laboratory of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing, 100081, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China; Corresponding author.College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China; Institute of Quality Standard & Testing Technology for Agro-Products, Key Laboratory of Agro-food Safety and Quality, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing, 100081, China; Corresponding author. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.A high intake of sugar-sweetened fruity beverage (FB) is associated with a higher risk of metabolic syndromes, but the health outcome of 100% fruit juice (FJ) intake remains unclear. We aim to reveal health outcomes of diet intervention (FJ or FB) with system profiling via interaction of gut microbiota and metabolomics in a rat (Rattus norvegicus) model. Firstly, the glucose, sucrose, fructose, and bioactive metabolites of FJ and FB were analyzed, and FJ possessed higher sucrose and flavonoids, while FB showed higher glucose and fructose. Secondly, C0 was set as the control group on Day 0, and a 4-week diet invention was performed to control, FJ-intake, and FB-intake groups with normal saline, FJ, and FB, respectively. The results showed that FJ improved alpha diversity and decreased the Firmicutes/Bacteroidota ratio (F/B ratio) of gut microbiota and prevented insulin resistance. However, FB possessed unchanged microbial diversity and enhanced F/B ratio, causing insulin resistance with renal triglyceride accumulation. In summary, FJ, although naturally containing similar amounts of total free sugars as FB, could be a healthier drink choice.http://www.sciencedirect.com/science/article/pii/S2665927123000229Fruit juiceFruity beverage100% orange JuiceOrange flavored beverageGut microbiotaKidney |
| spellingShingle | Kewen Wang Yang Zhao Lei Xu Xiaojun Liao Zhenzhen Xu Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats Current Research in Food Science Fruit juice Fruity beverage 100% orange Juice Orange flavored beverage Gut microbiota Kidney |
| title | Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats |
| title_full | Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats |
| title_fullStr | Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats |
| title_full_unstemmed | Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats |
| title_short | Health outcomes of 100% orange juice and orange flavored beverage: A comparative analysis of gut microbiota and metabolomics in rats |
| title_sort | health outcomes of 100 orange juice and orange flavored beverage a comparative analysis of gut microbiota and metabolomics in rats |
| topic | Fruit juice Fruity beverage 100% orange Juice Orange flavored beverage Gut microbiota Kidney |
| url | http://www.sciencedirect.com/science/article/pii/S2665927123000229 |
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