Virus-Encoded Complement Regulators: Current Status
Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and boosting the antiviral innate and acquired immune re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/2/208 |
| _version_ | 1827596821640249344 |
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| author | Anwesha Sinha Anup Kumar Singh Trupti Satish Kadni Jayati Mullick Arvind Sahu |
| author_facet | Anwesha Sinha Anup Kumar Singh Trupti Satish Kadni Jayati Mullick Arvind Sahu |
| author_sort | Anwesha Sinha |
| collection | DOAJ |
| description | Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and boosting the antiviral innate and acquired immune responses. Thus, the system imposes a strong selection pressure on viruses. Consequently, viruses have evolved multiple countermeasures against host complement. A major mechanism employed by viruses to subvert the complement system is encoding proteins that target complement. Since viruses have limited genome size, most of these proteins are multifunctional in nature. In this review, we provide up to date information on the structure and complement regulatory functions of various viral proteins. |
| first_indexed | 2024-03-09T03:15:54Z |
| format | Article |
| id | doaj.art-5e7110c35b214198a4dc4c98ce82ebb0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T03:15:54Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5e7110c35b214198a4dc4c98ce82ebb02023-12-03T15:19:09ZengMDPI AGViruses1999-49152021-01-0113220810.3390/v13020208Virus-Encoded Complement Regulators: Current StatusAnwesha Sinha0Anup Kumar Singh1Trupti Satish Kadni2Jayati Mullick3Arvind Sahu4Complement Biology Laboratory, National Centre for Cell Science, S. P. Pune University Campus, Ganeskhind, Pune 411007, IndiaComplement Biology Laboratory, National Centre for Cell Science, S. P. Pune University Campus, Ganeskhind, Pune 411007, IndiaComplement Biology Laboratory, National Centre for Cell Science, S. P. Pune University Campus, Ganeskhind, Pune 411007, IndiaPolio Virology Group, Microbial Containment Complex, ICMR-National Institute of Virology, Pune 411021, IndiaComplement Biology Laboratory, National Centre for Cell Science, S. P. Pune University Campus, Ganeskhind, Pune 411007, IndiaViruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and boosting the antiviral innate and acquired immune responses. Thus, the system imposes a strong selection pressure on viruses. Consequently, viruses have evolved multiple countermeasures against host complement. A major mechanism employed by viruses to subvert the complement system is encoding proteins that target complement. Since viruses have limited genome size, most of these proteins are multifunctional in nature. In this review, we provide up to date information on the structure and complement regulatory functions of various viral proteins.https://www.mdpi.com/1999-4915/13/2/208viral immune evasioncomplementinnate immunitypathogenesisPoxvirusHerpesvirus |
| spellingShingle | Anwesha Sinha Anup Kumar Singh Trupti Satish Kadni Jayati Mullick Arvind Sahu Virus-Encoded Complement Regulators: Current Status Viruses viral immune evasion complement innate immunity pathogenesis Poxvirus Herpesvirus |
| title | Virus-Encoded Complement Regulators: Current Status |
| title_full | Virus-Encoded Complement Regulators: Current Status |
| title_fullStr | Virus-Encoded Complement Regulators: Current Status |
| title_full_unstemmed | Virus-Encoded Complement Regulators: Current Status |
| title_short | Virus-Encoded Complement Regulators: Current Status |
| title_sort | virus encoded complement regulators current status |
| topic | viral immune evasion complement innate immunity pathogenesis Poxvirus Herpesvirus |
| url | https://www.mdpi.com/1999-4915/13/2/208 |
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