Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia
The successful management of cervical intraepithelial neoplasia (CIN) with proper screening and treatment methods could prevent cervical cancer progression. We propose a bioimpedance spectroscopic measurement device and a multi-electrode probe as an independent screening tool for CIN. To evaluate th...
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2354 |
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| author | Tong In Oh Min Ji Kang You Jeong Jeong Tingting Zhang Seung Geun Yeo Dong Choon Park |
| author_facet | Tong In Oh Min Ji Kang You Jeong Jeong Tingting Zhang Seung Geun Yeo Dong Choon Park |
| author_sort | Tong In Oh |
| collection | DOAJ |
| description | The successful management of cervical intraepithelial neoplasia (CIN) with proper screening and treatment methods could prevent cervical cancer progression. We propose a bioimpedance spectroscopic measurement device and a multi-electrode probe as an independent screening tool for CIN. To evaluate the performance of this screening method, we enrolled 123 patients, including 69 patients with suspected CIN and 54 control patients without cervical dysplasia who underwent a hysterectomy for benign disease (non-CIN). Following conization, the electrical properties of the excised cervical tissue were characterized using an electrical bioimpedance spectroscopy-based multi-electrode probe. Twenty-eight multifrequency voltages were collected through the two concentric array electrodes via a sensitivity-optimized measurement protocol based on an electrical energy concentration method. The electrical properties of the CIN and non-CIN groups were compared with the results of the pathology reports. Reconstructed resistivity tended to decrease in the CIN and non-CIN groups as frequency increased. Reconstructed resistivity from 625 Hz to 50 kHz differed significantly between the CIN and non-CIN groups (<i>p</i> < 0.001). Using 100 kHz as the reference, the difference between the CIN and non-CIN groups was significant. Based on the difference in reconstructed resistivity between 100 kHz and the other frequencies, this method had a sensitivity of 94.3%, a specificity of 84%, and an accuracy of 90% in CIN screening. The feasibility of noninvasive CIN screening was confirmed through the difference in the frequency spectra evaluated in the excised tissue using the electrical bioimpedance spectroscopy-based multi-electrode screening probe. |
| first_indexed | 2024-03-10T04:18:56Z |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:18:56Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5e7245e90ff04e4887fd06a0e5d3e6ba2023-11-23T07:54:54ZengMDPI AGDiagnostics2075-44182021-12-011112235410.3390/diagnostics11122354Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial NeoplasiaTong In Oh0Min Ji Kang1You Jeong Jeong2Tingting Zhang3Seung Geun Yeo4Dong Choon Park5Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul 02447, KoreaMedical Science Research Institute, Kyung Hee University Medical Center, Seoul 02447, KoreaDepartment of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaThe successful management of cervical intraepithelial neoplasia (CIN) with proper screening and treatment methods could prevent cervical cancer progression. We propose a bioimpedance spectroscopic measurement device and a multi-electrode probe as an independent screening tool for CIN. To evaluate the performance of this screening method, we enrolled 123 patients, including 69 patients with suspected CIN and 54 control patients without cervical dysplasia who underwent a hysterectomy for benign disease (non-CIN). Following conization, the electrical properties of the excised cervical tissue were characterized using an electrical bioimpedance spectroscopy-based multi-electrode probe. Twenty-eight multifrequency voltages were collected through the two concentric array electrodes via a sensitivity-optimized measurement protocol based on an electrical energy concentration method. The electrical properties of the CIN and non-CIN groups were compared with the results of the pathology reports. Reconstructed resistivity tended to decrease in the CIN and non-CIN groups as frequency increased. Reconstructed resistivity from 625 Hz to 50 kHz differed significantly between the CIN and non-CIN groups (<i>p</i> < 0.001). Using 100 kHz as the reference, the difference between the CIN and non-CIN groups was significant. Based on the difference in reconstructed resistivity between 100 kHz and the other frequencies, this method had a sensitivity of 94.3%, a specificity of 84%, and an accuracy of 90% in CIN screening. The feasibility of noninvasive CIN screening was confirmed through the difference in the frequency spectra evaluated in the excised tissue using the electrical bioimpedance spectroscopy-based multi-electrode screening probe.https://www.mdpi.com/2075-4418/11/12/2354CINelectrical impedance spectrumcancer screeningbioimpedance spectroscopymulti-electrode screening probe |
| spellingShingle | Tong In Oh Min Ji Kang You Jeong Jeong Tingting Zhang Seung Geun Yeo Dong Choon Park Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia Diagnostics CIN electrical impedance spectrum cancer screening bioimpedance spectroscopy multi-electrode screening probe |
| title | Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia |
| title_full | Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia |
| title_fullStr | Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia |
| title_full_unstemmed | Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia |
| title_short | Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia |
| title_sort | tissue characterization using an electrical bioimpedance spectroscopy based multi electrode probe to screen for cervical intraepithelial neoplasia |
| topic | CIN electrical impedance spectrum cancer screening bioimpedance spectroscopy multi-electrode screening probe |
| url | https://www.mdpi.com/2075-4418/11/12/2354 |
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