Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study
Abstract Background The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA). Methods The study is a cohort study with consecutive cases of newly diagnosed Finnish patients with JIA accordi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-023-00878-9 |
| _version_ | 1827724046217773056 |
|---|---|
| author | Suvi Oili Orvokki Peltoniemi Mia Glerup Pekka Lahdenne Kari K Eklund Kristiina Aalto |
| author_facet | Suvi Oili Orvokki Peltoniemi Mia Glerup Pekka Lahdenne Kari K Eklund Kristiina Aalto |
| author_sort | Suvi Oili Orvokki Peltoniemi |
| collection | DOAJ |
| description | Abstract Background The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA). Methods The study is a cohort study with consecutive cases of newly diagnosed Finnish patients with JIA according to the International League of Associations for Rheumatology (ILAR) criteria [1]. Patients were enrolled between 1997 and 2000 from a defined area of Southern Finland. Clinical data including disease activity and serology were registered during a mean period of 17.5 years. Results 159 patients completed the 18-year follow-up study. HLA-B27 was available for 151 patients, of which 25% were HLA-B27 positive. Chronic uveitis was diagnosed in 30% of HLA-B27 positive and 29% of HLA-B27 negative patients. HLA-B27 positive patients had a lower prevalence of temporomandibular (TMJ) involvement than the antigen negative ones, 19% versus 28%. None of the HLA-B27 positive patients had cervical spine affected compared to 11% of antigen negative patients (p = 0.022). Of the HLA-B27 positive patients, 54% had had biological medication at some point during follow-up versus 25% in the negative group (p = 0.003). At last follow-up, 32% of antigen positive patients were not in remission compared to 18% of the antigen negative (p = 0.017). Conclusions The use of biological medication was more common in HLA-B27 positive patients with JIA. At the 18-year follow-up, more antigen positive patients had active disease compared HLA-B27 negative patients. This real-world follow-up study indicates that the prospects for worse outcome with HLA-B27 positivity in long-term should be taken into consideration. |
| first_indexed | 2024-03-10T22:09:20Z |
| format | Article |
| id | doaj.art-5e73a098a240424c95fb77a7c04c3352 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-03-10T22:09:20Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-5e73a098a240424c95fb77a7c04c33522023-11-19T12:39:57ZengBMCPediatric Rheumatology Online Journal1546-00962023-09-012111710.1186/s12969-023-00878-9Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up studySuvi Oili Orvokki Peltoniemi0Mia Glerup1Pekka Lahdenne2Kari K Eklund3Kristiina Aalto4Department of Rheumatology, Helsinki University Hospital and University of HelsinkiDepartment of Paediatric and Adolescent Medicine, Aarhus University HospitalDepartment of Paediatrics, New Children’s Hospital, Helsinki University Hospital and University of HelsinkiDepartment of Rheumatology, Helsinki University Hospital and University of HelsinkiDepartment of Paediatrics, New Children’s Hospital, Helsinki University Hospital and University of HelsinkiAbstract Background The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA). Methods The study is a cohort study with consecutive cases of newly diagnosed Finnish patients with JIA according to the International League of Associations for Rheumatology (ILAR) criteria [1]. Patients were enrolled between 1997 and 2000 from a defined area of Southern Finland. Clinical data including disease activity and serology were registered during a mean period of 17.5 years. Results 159 patients completed the 18-year follow-up study. HLA-B27 was available for 151 patients, of which 25% were HLA-B27 positive. Chronic uveitis was diagnosed in 30% of HLA-B27 positive and 29% of HLA-B27 negative patients. HLA-B27 positive patients had a lower prevalence of temporomandibular (TMJ) involvement than the antigen negative ones, 19% versus 28%. None of the HLA-B27 positive patients had cervical spine affected compared to 11% of antigen negative patients (p = 0.022). Of the HLA-B27 positive patients, 54% had had biological medication at some point during follow-up versus 25% in the negative group (p = 0.003). At last follow-up, 32% of antigen positive patients were not in remission compared to 18% of the antigen negative (p = 0.017). Conclusions The use of biological medication was more common in HLA-B27 positive patients with JIA. At the 18-year follow-up, more antigen positive patients had active disease compared HLA-B27 negative patients. This real-world follow-up study indicates that the prospects for worse outcome with HLA-B27 positivity in long-term should be taken into consideration.https://doi.org/10.1186/s12969-023-00878-9Juvenile idiopathic arthritisHLA-B27Follow-up studyRemission |
| spellingShingle | Suvi Oili Orvokki Peltoniemi Mia Glerup Pekka Lahdenne Kari K Eklund Kristiina Aalto Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study Pediatric Rheumatology Online Journal Juvenile idiopathic arthritis HLA-B27 Follow-up study Remission |
| title | Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study |
| title_full | Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study |
| title_fullStr | Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study |
| title_full_unstemmed | Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study |
| title_short | Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study |
| title_sort | disease characteristics of hla b27 positive and negative finnish patients with juvenile idiopathic arthritis results of the 18 year cohort follow up study |
| topic | Juvenile idiopathic arthritis HLA-B27 Follow-up study Remission |
| url | https://doi.org/10.1186/s12969-023-00878-9 |
| work_keys_str_mv | AT suvioiliorvokkipeltoniemi diseasecharacteristicsofhlab27positiveandnegativefinnishpatientswithjuvenileidiopathicarthritisresultsofthe18yearcohortfollowupstudy AT miaglerup diseasecharacteristicsofhlab27positiveandnegativefinnishpatientswithjuvenileidiopathicarthritisresultsofthe18yearcohortfollowupstudy AT pekkalahdenne diseasecharacteristicsofhlab27positiveandnegativefinnishpatientswithjuvenileidiopathicarthritisresultsofthe18yearcohortfollowupstudy AT karikeklund diseasecharacteristicsofhlab27positiveandnegativefinnishpatientswithjuvenileidiopathicarthritisresultsofthe18yearcohortfollowupstudy AT kristiinaaalto diseasecharacteristicsofhlab27positiveandnegativefinnishpatientswithjuvenileidiopathicarthritisresultsofthe18yearcohortfollowupstudy |