A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients
Abstract Objective This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate c...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3985-2 |
| _version_ | 1828240761013927936 |
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| author | Mike Allan Mortensen Mie Holm Vilstrup Mads Hvid Poulsen Oke Gerke Poul Flemming Høilund-Carlsen Lars Lund |
| author_facet | Mike Allan Mortensen Mie Holm Vilstrup Mads Hvid Poulsen Oke Gerke Poul Flemming Høilund-Carlsen Lars Lund |
| author_sort | Mike Allan Mortensen |
| collection | DOAJ |
| description | Abstract Objective This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer. Results Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%). A median of 19 (range 10–41; n = 434) lymph nodes were removed per patient. Pelvic lymph nodes with detectable FDG uptake were seen in two patients only, but the FDG-avid lesion on PET did not correspond with pathological findings in either patient. We found a significant increase in maximal standardized uptake value of the prostate of around 30% between early and late imaging. We found no correlation between clinical findings after radical prostatectomy and PET measurements. |
| first_indexed | 2024-04-12T21:46:30Z |
| format | Article |
| id | doaj.art-5e7607e4aecf4e939b40c5a645b106c3 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-12T21:46:30Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-5e7607e4aecf4e939b40c5a645b106c32022-12-22T03:15:37ZengBMCBMC Research Notes1756-05002018-12-011111410.1186/s13104-018-3985-2A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patientsMike Allan Mortensen0Mie Holm Vilstrup1Mads Hvid Poulsen2Oke Gerke3Poul Flemming Høilund-Carlsen4Lars Lund5Department of Urology, Odense University HospitalDepartment of Nuclear Medicine, Odense University HospitalDepartment of Urology, Odense University HospitalDepartment of Nuclear Medicine, Odense University HospitalDepartment of Clinical Research, University of Southern DenmarkDepartment of Urology, Odense University HospitalAbstract Objective This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer. Results Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%). A median of 19 (range 10–41; n = 434) lymph nodes were removed per patient. Pelvic lymph nodes with detectable FDG uptake were seen in two patients only, but the FDG-avid lesion on PET did not correspond with pathological findings in either patient. We found a significant increase in maximal standardized uptake value of the prostate of around 30% between early and late imaging. We found no correlation between clinical findings after radical prostatectomy and PET measurements.http://link.springer.com/article/10.1186/s13104-018-3985-2Prostatic neoplasmsDiagnostic imagingPositron emission tomographyFluorodeoxyglucose |
| spellingShingle | Mike Allan Mortensen Mie Holm Vilstrup Mads Hvid Poulsen Oke Gerke Poul Flemming Høilund-Carlsen Lars Lund A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients BMC Research Notes Prostatic neoplasms Diagnostic imaging Positron emission tomography Fluorodeoxyglucose |
| title | A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients |
| title_full | A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients |
| title_fullStr | A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients |
| title_full_unstemmed | A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients |
| title_short | A prospective study on dual time 18F-FDG-PET/CT in high-risk prostate cancer patients |
| title_sort | prospective study on dual time 18f fdg pet ct in high risk prostate cancer patients |
| topic | Prostatic neoplasms Diagnostic imaging Positron emission tomography Fluorodeoxyglucose |
| url | http://link.springer.com/article/10.1186/s13104-018-3985-2 |
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