Thiol-disulphide homeostasis in noncomplicated chronic otitis media
Introduction: We hypothesized that oxidative stress plays a role in the pathogenesis of chronic otitis media, chronic mucosal inflammatory disease. We aimed to investigate a novel oxidative stress marker in this study. Materıals and methods: Thirty patient with chronic otitis media as the patient gr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Rabia Yılmaz
2019-06-01
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| Series: | Journal of Contemporary Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/726524 |
| _version_ | 1797860676990926848 |
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| author | Arife Sezgin Ahmet Akkoz Özcan Erel Mehmet Hakan Korkmaz Kazım Bozdemir Bülent Ulusoy |
| author_facet | Arife Sezgin Ahmet Akkoz Özcan Erel Mehmet Hakan Korkmaz Kazım Bozdemir Bülent Ulusoy |
| author_sort | Arife Sezgin |
| collection | DOAJ |
| description | Introduction: We
hypothesized that oxidative stress plays a role in the pathogenesis of chronic
otitis media, chronic mucosal inflammatory disease. We aimed to investigate a
novel oxidative stress marker in this study. Materıals and methods: Thirty
patient with chronic otitis media as the patient group and 30 healthy volunteer
subjects as the control group were admitted to the study. Blood samples were taken when they admitted to our clinic
before surgical intervention. In healthy volunteers, blood samples were taken
when they were admitted to our policlinic.
Thiol/disulphide levels were analyzed with a newly developed method by
Erel and Neselioglu.Results: 30 subjects were included in chronic otitis media
group (20 females, 10 males). 30
subjects were included in the control group (8 females and 22 males). Sex distribution
within the groups was significantly different (p=0.004). There was no
significant difference between groups with respect to the age distribution
(p=0.072). Measured native thiol, disulphide and total thiol values of the
groups were not significantly different from each other.
Conclusion: This study
demonstrated that although dynamic thiol/disulphide homeostasis was shifted
towards disulphide formation as a result of thiol oxidation in patients with
chronic otitis media. But we could not find any significant difference between
groups. |
| first_indexed | 2024-04-09T21:49:48Z |
| format | Article |
| id | doaj.art-5e76a560252340c3b5da231282ff839e |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:49:48Z |
| publishDate | 2019-06-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-5e76a560252340c3b5da231282ff839e2023-03-24T19:43:23ZengRabia YılmazJournal of Contemporary Medicine2667-71802019-06-019211912210.16899/jcm.5716331809Thiol-disulphide homeostasis in noncomplicated chronic otitis mediaArife Sezgin0Ahmet Akkoz1Özcan Erel2Mehmet Hakan Korkmaz3Kazım Bozdemir4Bülent Ulusoy5Atatürk Training and Research Hospital, Department of of Otorhinolaryngology, Ankara, TurkeyAlaca State Hospital, Department of Otorhinolaryngology, Çorum, TurkeyYıldırım Beyazıt University School of Medicine Department of Clinical Biochemistry, , Ankara, TurkeyYıldırım Beyazıt University School of Medicine, Department of Otorhinolaryngology, Ankara, TurkeyFACULTY OF MEDICINESELCUK UNIVERSITYIntroduction: We hypothesized that oxidative stress plays a role in the pathogenesis of chronic otitis media, chronic mucosal inflammatory disease. We aimed to investigate a novel oxidative stress marker in this study. Materıals and methods: Thirty patient with chronic otitis media as the patient group and 30 healthy volunteer subjects as the control group were admitted to the study. Blood samples were taken when they admitted to our clinic before surgical intervention. In healthy volunteers, blood samples were taken when they were admitted to our policlinic. Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu.Results: 30 subjects were included in chronic otitis media group (20 females, 10 males). 30 subjects were included in the control group (8 females and 22 males). Sex distribution within the groups was significantly different (p=0.004). There was no significant difference between groups with respect to the age distribution (p=0.072). Measured native thiol, disulphide and total thiol values of the groups were not significantly different from each other. Conclusion: This study demonstrated that although dynamic thiol/disulphide homeostasis was shifted towards disulphide formation as a result of thiol oxidation in patients with chronic otitis media. But we could not find any significant difference between groups.https://dergipark.org.tr/tr/download/article-file/726524oxidative stressthiol/disulphide homeostazisikronik otitis mediaoxidative stressthiol/disulphide homeostasischronic otitis media |
| spellingShingle | Arife Sezgin Ahmet Akkoz Özcan Erel Mehmet Hakan Korkmaz Kazım Bozdemir Bülent Ulusoy Thiol-disulphide homeostasis in noncomplicated chronic otitis media Journal of Contemporary Medicine oxidative stress thiol/disulphide homeostazisi kronik otitis media oxidative stress thiol/disulphide homeostasis chronic otitis media |
| title | Thiol-disulphide homeostasis in noncomplicated chronic otitis media |
| title_full | Thiol-disulphide homeostasis in noncomplicated chronic otitis media |
| title_fullStr | Thiol-disulphide homeostasis in noncomplicated chronic otitis media |
| title_full_unstemmed | Thiol-disulphide homeostasis in noncomplicated chronic otitis media |
| title_short | Thiol-disulphide homeostasis in noncomplicated chronic otitis media |
| title_sort | thiol disulphide homeostasis in noncomplicated chronic otitis media |
| topic | oxidative stress thiol/disulphide homeostazisi kronik otitis media oxidative stress thiol/disulphide homeostasis chronic otitis media |
| url | https://dergipark.org.tr/tr/download/article-file/726524 |
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