Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice
The microbiome is an important player within physiological homeostasis of the body but also in pathophysiological derailments. Chronic social stress is a challenge to the organism, which results in psychological illnesses such as depression in some individuals and can be counterbalanced by others, n...
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MDPI AG
2022-05-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/6/1077 |
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| author | Malena dos Santos Guilherme Francesco Valeri Jennifer Winter Marianne B. Müller Andreas Schwiertz Kristina Endres |
| author_facet | Malena dos Santos Guilherme Francesco Valeri Jennifer Winter Marianne B. Müller Andreas Schwiertz Kristina Endres |
| author_sort | Malena dos Santos Guilherme |
| collection | DOAJ |
| description | The microbiome is an important player within physiological homeostasis of the body but also in pathophysiological derailments. Chronic social stress is a challenge to the organism, which results in psychological illnesses such as depression in some individuals and can be counterbalanced by others, namely resilient individuals. In this study, we wanted to elucidate the potential contribution of the microbiome to promote resilience. Male mice were subjected to the classical chronic social defeat paradigm. Defeated or undefeated mice were either controls (receiving normal drinking water) or pre-treated with antibiotics or probiotics. Following social defeat, resilient behavior was assessed by means of the social interaction test. Neither depletion nor probiotic-shifted alteration of the microbiome influenced stress-associated behavioral outcomes. Nevertheless, clear changes in microbiota composition due to the defeat stress were observed such as elevated <i>Bacteroides</i> spp. This stress-induced increase in <i>Bacteroides</i> in male mice could be confirmed in a related social stress paradigm (instable social hierarchy) in females. This indicates that while manipulation of the microbiome via the antibiotics- and probiotics-treatment regime used here has no direct impact on modulating individual stress susceptibility in rodents, it clearly affects the microbiome in the second line and in a sex-independent manner regarding <i>Bacteroides</i>. |
| first_indexed | 2024-03-09T23:01:01Z |
| format | Article |
| id | doaj.art-5e79c9295c6d40d196706ddfdf5c7e91 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T23:01:01Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
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| series | Microorganisms |
| spelling | doaj.art-5e79c9295c6d40d196706ddfdf5c7e912023-11-23T18:02:35ZengMDPI AGMicroorganisms2076-26072022-05-01106107710.3390/microorganisms10061077Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type MiceMalena dos Santos Guilherme0Francesco Valeri1Jennifer Winter2Marianne B. Müller3Andreas Schwiertz4Kristina Endres5Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, GermanyDepartment of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, GermanyInstitute for Human Genetics, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, GermanyDepartment of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, GermanyMVZ Institute fuer Mikrooekologie GmbH, 35745 Herborn, GermanyDepartment of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, GermanyThe microbiome is an important player within physiological homeostasis of the body but also in pathophysiological derailments. Chronic social stress is a challenge to the organism, which results in psychological illnesses such as depression in some individuals and can be counterbalanced by others, namely resilient individuals. In this study, we wanted to elucidate the potential contribution of the microbiome to promote resilience. Male mice were subjected to the classical chronic social defeat paradigm. Defeated or undefeated mice were either controls (receiving normal drinking water) or pre-treated with antibiotics or probiotics. Following social defeat, resilient behavior was assessed by means of the social interaction test. Neither depletion nor probiotic-shifted alteration of the microbiome influenced stress-associated behavioral outcomes. Nevertheless, clear changes in microbiota composition due to the defeat stress were observed such as elevated <i>Bacteroides</i> spp. This stress-induced increase in <i>Bacteroides</i> in male mice could be confirmed in a related social stress paradigm (instable social hierarchy) in females. This indicates that while manipulation of the microbiome via the antibiotics- and probiotics-treatment regime used here has no direct impact on modulating individual stress susceptibility in rodents, it clearly affects the microbiome in the second line and in a sex-independent manner regarding <i>Bacteroides</i>.https://www.mdpi.com/2076-2607/10/6/1077chronic social stressresiliencesusceptibilitymouse modelmicrobiomeantibiotics |
| spellingShingle | Malena dos Santos Guilherme Francesco Valeri Jennifer Winter Marianne B. Müller Andreas Schwiertz Kristina Endres Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice Microorganisms chronic social stress resilience susceptibility mouse model microbiome antibiotics |
| title | Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice |
| title_full | Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice |
| title_fullStr | Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice |
| title_full_unstemmed | Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice |
| title_short | Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice |
| title_sort | resilience and the gut microbiome insights from chronically socially stressed wild type mice |
| topic | chronic social stress resilience susceptibility mouse model microbiome antibiotics |
| url | https://www.mdpi.com/2076-2607/10/6/1077 |
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