Tissue-Mimicking Geometrical Constraints Stimulate Tissue-Like Constitution and Activity of Mouse Neonatal and Human-Induced Pluripotent Stem Cell-Derived Cardiac Myocytes

Tissue-Mimicking Geometrical Constraints Stimulate Tissue-Like Constitution and Activity of Mouse Neonatal and Human-Induced Pluripotent Stem Cell-Derived Cardiac Myocytes

The present work addresses the question of to what extent a geometrical support acts as a physiological determining template in the setup of artificial cardiac tissue. Surface patterns with alternating concave to convex transitions of cell size dimensions were used to organize and orientate human-in...

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Bibliographic Details
Main Authors: Götz Pilarczyk, Alexandra Raulf, Manuel Gunkel, Bernd K. Fleischmann, Robert Lemor, Michael Hausmann
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Journal of Functional Biomaterials
Subjects:
hIPSC-derived cardiac myocytes
surface pattern
cardiac tissue engineering
stem cells
structure-based cardiac arrhythmia
Online Access:http://www.mdpi.com/2079-4983/7/1/1

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