Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children
Background Lactose intolerance is a common complication of diarrhea in young children particularly that due to rotaviral infec- tion. A meta-analysis study evaluated the use of undiluted lactose containing formula or cow’s milk during an episode of diarrhea. It was concluded that routine dilution of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/956 |
| _version_ | 1828857704836235264 |
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| author | Sri Lestari Agus Firmansyah Zakiudin Munasir |
| author_facet | Sri Lestari Agus Firmansyah Zakiudin Munasir |
| author_sort | Sri Lestari |
| collection | DOAJ |
| description | Background Lactose intolerance is a common complication of
diarrhea in young children particularly that due to rotaviral infec-
tion. A meta-analysis study evaluated the use of undiluted lactose
containing formula or cow’s milk during an episode of diarrhea. It
was concluded that routine dilution of milk and the use of lactose-
free milk formula are not necessary.
Objective To evaluate the effect of lactose free formula compared
with lactose-containing milk formula during acute diarrheal episode
in outpatient setting.
Methods A total of 56 children with acute diarrhea with mild-mod-
erate or no dehydration attending to the outpatient clinic were ran-
domly assigned to receive a lactose-free formula (Nestle Nan ® free
lactose) or lactose-containing milk formula (Nestle Nan 2 ® formula)
after initial rehydration. Comparisons of stool frequency, duration
of diarrhea and treatment failure rates were noted. Treatment fail-
ure was defined as clinical requirement for intravenous infusion
after rehydration or prolonged diarrhea (>7 days).
Results The duration of diarrhea was similar between the two
groups (P=0.195) in spite of two children who received lactose
free formula did not resolve from diarrhea within 7 days of treat-
ment. The median of stool frequency was indifferent in the two
groups (P=0.199) in rotavirus gastroenteritis; there were no differ-
ences in the duration of diarrhea or the stool frequency.
Conclusion Children without dehydration or with mild dehydra-
tion tolerated to lactose-containing formula as well as lactose-free
formula for the treatment of acute diarrhea |
| first_indexed | 2024-12-13T01:42:00Z |
| format | Article |
| id | doaj.art-5e7e3d935ffb43bebbfa0ff9ee416805 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-13T01:42:00Z |
| publishDate | 2016-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-5e7e3d935ffb43bebbfa0ff9ee4168052022-12-22T00:03:44ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-01466271510.14238/pi46.6.2006.271-5810Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in childrenSri LestariAgus FirmansyahZakiudin MunasirBackground Lactose intolerance is a common complication of diarrhea in young children particularly that due to rotaviral infec- tion. A meta-analysis study evaluated the use of undiluted lactose containing formula or cow’s milk during an episode of diarrhea. It was concluded that routine dilution of milk and the use of lactose- free milk formula are not necessary. Objective To evaluate the effect of lactose free formula compared with lactose-containing milk formula during acute diarrheal episode in outpatient setting. Methods A total of 56 children with acute diarrhea with mild-mod- erate or no dehydration attending to the outpatient clinic were ran- domly assigned to receive a lactose-free formula (Nestle Nan ® free lactose) or lactose-containing milk formula (Nestle Nan 2 ® formula) after initial rehydration. Comparisons of stool frequency, duration of diarrhea and treatment failure rates were noted. Treatment fail- ure was defined as clinical requirement for intravenous infusion after rehydration or prolonged diarrhea (>7 days). Results The duration of diarrhea was similar between the two groups (P=0.195) in spite of two children who received lactose free formula did not resolve from diarrhea within 7 days of treat- ment. The median of stool frequency was indifferent in the two groups (P=0.199) in rotavirus gastroenteritis; there were no differ- ences in the duration of diarrhea or the stool frequency. Conclusion Children without dehydration or with mild dehydra- tion tolerated to lactose-containing formula as well as lactose-free formula for the treatment of acute diarrheahttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/956diarrheamilk formulalactose-free formulalactose intolerance |
| spellingShingle | Sri Lestari Agus Firmansyah Zakiudin Munasir Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children Paediatrica Indonesiana diarrhea milk formula lactose-free formula lactose intolerance |
| title | Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children |
| title_full | Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children |
| title_fullStr | Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children |
| title_full_unstemmed | Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children |
| title_short | Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children |
| title_sort | double blind clinical trial on a lactose free and a lactose containing formula in the treatment of acute diarrhea in children |
| topic | diarrhea milk formula lactose-free formula lactose intolerance |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/956 |
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