Practical Considerations for Use of Direct Oral Anticoagulants in Children
Direct oral anticoagulants (DOACs) provide an attractive alternative for the management and prevention of thrombosis in pediatric patients. With multiple ongoing and published pediatric trials and recent regulatory approval of dabigatran and rivaroxaban, the landscape of pediatric anticoagulation is...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.860369/full |
| _version_ | 1811297744337240064 |
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| author | Hilary Whitworth Leslie Raffini |
| author_facet | Hilary Whitworth Leslie Raffini |
| author_sort | Hilary Whitworth |
| collection | DOAJ |
| description | Direct oral anticoagulants (DOACs) provide an attractive alternative for the management and prevention of thrombosis in pediatric patients. With multiple ongoing and published pediatric trials and recent regulatory approval of dabigatran and rivaroxaban, the landscape of pediatric anticoagulation is rapidly changing. However, as pediatricians gain experience with these drugs, it is important to be mindful of pediatric-specific considerations that may limit the use of DOACs in certain children and adolescents. While there is increasing adult data and experience, there is a paucity of real-world evidence to guide the use of these drugs in children who would not have met clinical trial inclusion criteria. In this mini review, we summarize pediatric specific data, areas for future research, and practical considerations for the use of DOACs in children and adolescents. |
| first_indexed | 2024-04-13T06:09:43Z |
| format | Article |
| id | doaj.art-5e7fec2f3a01449cb95f34e91d6d5e96 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T06:09:43Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-5e7fec2f3a01449cb95f34e91d6d5e962022-12-22T02:59:06ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-04-011010.3389/fped.2022.860369860369Practical Considerations for Use of Direct Oral Anticoagulants in ChildrenHilary WhitworthLeslie RaffiniDirect oral anticoagulants (DOACs) provide an attractive alternative for the management and prevention of thrombosis in pediatric patients. With multiple ongoing and published pediatric trials and recent regulatory approval of dabigatran and rivaroxaban, the landscape of pediatric anticoagulation is rapidly changing. However, as pediatricians gain experience with these drugs, it is important to be mindful of pediatric-specific considerations that may limit the use of DOACs in certain children and adolescents. While there is increasing adult data and experience, there is a paucity of real-world evidence to guide the use of these drugs in children who would not have met clinical trial inclusion criteria. In this mini review, we summarize pediatric specific data, areas for future research, and practical considerations for the use of DOACs in children and adolescents.https://www.frontiersin.org/articles/10.3389/fped.2022.860369/fullpediatricthrombosisVTEanticoagulationdirect oral anticoagulant |
| spellingShingle | Hilary Whitworth Leslie Raffini Practical Considerations for Use of Direct Oral Anticoagulants in Children Frontiers in Pediatrics pediatric thrombosis VTE anticoagulation direct oral anticoagulant |
| title | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
| title_full | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
| title_fullStr | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
| title_full_unstemmed | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
| title_short | Practical Considerations for Use of Direct Oral Anticoagulants in Children |
| title_sort | practical considerations for use of direct oral anticoagulants in children |
| topic | pediatric thrombosis VTE anticoagulation direct oral anticoagulant |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.860369/full |
| work_keys_str_mv | AT hilarywhitworth practicalconsiderationsforuseofdirectoralanticoagulantsinchildren AT leslieraffini practicalconsiderationsforuseofdirectoralanticoagulantsinchildren |