Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy
Abstract Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expanding utility for near infrared (NIR) dyes in bio-imaging/theranostics. However, r...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02133-5 |
| _version_ | 1797451606696919040 |
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| author | Yafang Dong Peng Xia Xiaolong Xu Jing Shen Youbin Ding Yuke Jiang Huifang Wang Xin Xie Xiaodong Zhang Weihua Li Zhijie Li Jigang Wang Shan-Chao Zhao |
| author_facet | Yafang Dong Peng Xia Xiaolong Xu Jing Shen Youbin Ding Yuke Jiang Huifang Wang Xin Xie Xiaodong Zhang Weihua Li Zhijie Li Jigang Wang Shan-Chao Zhao |
| author_sort | Yafang Dong |
| collection | DOAJ |
| description | Abstract Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expanding utility for near infrared (NIR) dyes in bio-imaging/theranostics. However, reports on CR dyes for PTT are scarce most likely due to the short of the efficacious delivery strategies to achieve specific accumulation in diseased tissues to induce PTT. Extracellular vesicles (EVs) are multifunctional nanoparticle systems that function as safe platform for disease theragnostics, which provide potential benefits in extensive biomedical applications. Here, we developed a novel delivery system for photothermal molecules based on a CR dye that exerts photothermal activity through CDH17 nanobody-engineered EVs. The formed CR@E8-EVs showed strong NIR absorption, excellent photothermal performance, good biological compatibility and superb active tumor-targeting capability. The CR@E8-EVs can not only visualize and feature the tumors through CR intrinsic property as a photoacoustic imaging (PAI) agent, but also effectively retard the tumor growth under laser irradiation to perform PTT. It is expected that the engineered EVs will become a novel delivery vehicle of small organic photothermal agents (SOPTAs) in future clinical PTT applications. |
| first_indexed | 2024-03-09T14:57:05Z |
| format | Article |
| id | doaj.art-5e80b1974ae941e384b13b446b8f2e40 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-09T14:57:05Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-5e80b1974ae941e384b13b446b8f2e402023-11-26T14:08:30ZengBMCJournal of Nanobiotechnology1477-31552023-11-0121111510.1186/s12951-023-02133-5Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapyYafang Dong0Peng Xia1Xiaolong Xu2Jing Shen3Youbin Ding4Yuke Jiang5Huifang Wang6Xin Xie7Xiaodong Zhang8Weihua Li9Zhijie Li10Jigang Wang11Shan-Chao Zhao12Department of Urology, the Third Affiliated Hospital of Southern Medical UniversityDepartment of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyDepartment of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyDepartment of Oncology, Department of Infectious Disease, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyDepartment of Medical Imaging, The Third Affiliated Hospital of Southern Medical UniversityDepartment of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyDepartment of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyDepartment of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyDepartment of Medical Imaging, The Third Affiliated Hospital of Southern Medical UniversityMedical imaging department, Shenzhen Second People’s Hospital/the First Affiliated Hospital, Shenzhen University Health Science CenterDepartment of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyDepartment of Urology, the Third Affiliated Hospital of Southern Medical UniversityDepartment of Urology, the Third Affiliated Hospital of Southern Medical UniversityAbstract Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expanding utility for near infrared (NIR) dyes in bio-imaging/theranostics. However, reports on CR dyes for PTT are scarce most likely due to the short of the efficacious delivery strategies to achieve specific accumulation in diseased tissues to induce PTT. Extracellular vesicles (EVs) are multifunctional nanoparticle systems that function as safe platform for disease theragnostics, which provide potential benefits in extensive biomedical applications. Here, we developed a novel delivery system for photothermal molecules based on a CR dye that exerts photothermal activity through CDH17 nanobody-engineered EVs. The formed CR@E8-EVs showed strong NIR absorption, excellent photothermal performance, good biological compatibility and superb active tumor-targeting capability. The CR@E8-EVs can not only visualize and feature the tumors through CR intrinsic property as a photoacoustic imaging (PAI) agent, but also effectively retard the tumor growth under laser irradiation to perform PTT. It is expected that the engineered EVs will become a novel delivery vehicle of small organic photothermal agents (SOPTAs) in future clinical PTT applications.https://doi.org/10.1186/s12951-023-02133-5Imaging-guided photothermal therapySmall organic photothermal agentsCroconaine dyesExtracellular vesiclesActive tumor targeting |
| spellingShingle | Yafang Dong Peng Xia Xiaolong Xu Jing Shen Youbin Ding Yuke Jiang Huifang Wang Xin Xie Xiaodong Zhang Weihua Li Zhijie Li Jigang Wang Shan-Chao Zhao Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy Journal of Nanobiotechnology Imaging-guided photothermal therapy Small organic photothermal agents Croconaine dyes Extracellular vesicles Active tumor targeting |
| title | Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy |
| title_full | Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy |
| title_fullStr | Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy |
| title_full_unstemmed | Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy |
| title_short | Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy |
| title_sort | targeted delivery of organic small molecule photothermal materials with engineered extracellular vesicles for imaging guided tumor photothermal therapy |
| topic | Imaging-guided photothermal therapy Small organic photothermal agents Croconaine dyes Extracellular vesicles Active tumor targeting |
| url | https://doi.org/10.1186/s12951-023-02133-5 |
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