Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis
Background and Objectives: The number of lymph nodes found harboring metastasis can be impacted by the extent of harvest. Guidelines recommend 12 lymph nodes for adequate lymphadenectomy to predict long-term oncologic outcomes, yet different cut-offs remain unevaluated. The aim of this review was to...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Surgery in Practice and Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666262023000360 |
| _version_ | 1797690199684153344 |
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| author | Simarpreet Ichhpuniani Tyler McKechnie Jay Lee Jeremy Biro Yung Lee Lily Park Aristithes Doumouras Dennis Hong Cagla Eskicioglu |
| author_facet | Simarpreet Ichhpuniani Tyler McKechnie Jay Lee Jeremy Biro Yung Lee Lily Park Aristithes Doumouras Dennis Hong Cagla Eskicioglu |
| author_sort | Simarpreet Ichhpuniani |
| collection | DOAJ |
| description | Background and Objectives: The number of lymph nodes found harboring metastasis can be impacted by the extent of harvest. Guidelines recommend 12 lymph nodes for adequate lymphadenectomy to predict long-term oncologic outcomes, yet different cut-offs remain unevaluated. The aim of this review was to determine cut-offs that may predict survival outcomes. Methods: Medline, Embase, and CENTRAL were systematically searched. Articles were included if they compared overall survival (OS) or disease-free survival (DFS) above and below a lymph node harvest cut-off. Studies solely examining rectal cancer or stage-IV disease were excluded. Pairwise meta-analyses using inverse variance random effects were performed. Results: From 2587 citations, 20 studies with 854,359 patients (51.9% female, mean age: 68.9) were included, with 19 studies included in quantitative synthesis. A lymph node harvest cut-off of 12 predicted improved five-year OS (7 studies; OR 1.11, 95% CI 1.08–1.14, p<0.00001). A cut-off as low as 7 was associated with improved five-year OS (2 studies; OR 1.16, 95% CI 1.08–1.25, p<0.0001) and DFS (3 studies; OR 1.66, 95% CI 1.32–2.10, p<0.00001). All cut-offs greater than 12 demonstrated improved survival. Conclusions: A lymph node cut-off of 12 distinguishes differences in five-year oncologic outcomes. Contrarily, lymph node harvests other than 12 have not been rigorously studied and thus lack the statistical power to derive meaningful conclusions compared to the 12-lymph node cut-off. Nonetheless, it is possible that a lymph node harvest cut-offs less than 12 may be adequate in predicting long-term survival. Further prospective study evaluating cut-offs below 12 are warranted. |
| first_indexed | 2024-03-12T01:56:07Z |
| format | Article |
| id | doaj.art-5e80c80b47a74a128515c3607d85a9a7 |
| institution | Directory Open Access Journal |
| issn | 2666-2620 |
| language | English |
| last_indexed | 2024-03-12T01:56:07Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Surgery in Practice and Science |
| spelling | doaj.art-5e80c80b47a74a128515c3607d85a9a72023-09-08T04:33:57ZengElsevierSurgery in Practice and Science2666-26202023-09-0114100190Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysisSimarpreet Ichhpuniani0Tyler McKechnie1Jay Lee2Jeremy Biro3Yung Lee4Lily Park5Aristithes Doumouras6Dennis Hong7Cagla Eskicioglu8Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, CanadaDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, CanadaMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, CanadaMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, CanadaDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, CanadaDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, CanadaDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; Division of General Surgery, Department of Surgery, St. Joseph's Healthcare, Hamilton, Ontario, CanadaDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; Division of General Surgery, Department of Surgery, St. Joseph's Healthcare, Hamilton, Ontario, CanadaDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; Division of General Surgery, Department of Surgery, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Corresponding author at: Cagla Eskicioglu, Division of General Surgery Department of Surgery, McMaster University. St. Joseph's Healthcare, 50 Charlton Avenue East Hamilton, Ontario, L8N 4A6, Canada.Background and Objectives: The number of lymph nodes found harboring metastasis can be impacted by the extent of harvest. Guidelines recommend 12 lymph nodes for adequate lymphadenectomy to predict long-term oncologic outcomes, yet different cut-offs remain unevaluated. The aim of this review was to determine cut-offs that may predict survival outcomes. Methods: Medline, Embase, and CENTRAL were systematically searched. Articles were included if they compared overall survival (OS) or disease-free survival (DFS) above and below a lymph node harvest cut-off. Studies solely examining rectal cancer or stage-IV disease were excluded. Pairwise meta-analyses using inverse variance random effects were performed. Results: From 2587 citations, 20 studies with 854,359 patients (51.9% female, mean age: 68.9) were included, with 19 studies included in quantitative synthesis. A lymph node harvest cut-off of 12 predicted improved five-year OS (7 studies; OR 1.11, 95% CI 1.08–1.14, p<0.00001). A cut-off as low as 7 was associated with improved five-year OS (2 studies; OR 1.16, 95% CI 1.08–1.25, p<0.0001) and DFS (3 studies; OR 1.66, 95% CI 1.32–2.10, p<0.00001). All cut-offs greater than 12 demonstrated improved survival. Conclusions: A lymph node cut-off of 12 distinguishes differences in five-year oncologic outcomes. Contrarily, lymph node harvests other than 12 have not been rigorously studied and thus lack the statistical power to derive meaningful conclusions compared to the 12-lymph node cut-off. Nonetheless, it is possible that a lymph node harvest cut-offs less than 12 may be adequate in predicting long-term survival. Further prospective study evaluating cut-offs below 12 are warranted.http://www.sciencedirect.com/science/article/pii/S2666262023000360Colon cancerLymph nodesLymph node harvestLymphadenectomySurvivalColorectal Surgery |
| spellingShingle | Simarpreet Ichhpuniani Tyler McKechnie Jay Lee Jeremy Biro Yung Lee Lily Park Aristithes Doumouras Dennis Hong Cagla Eskicioglu Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis Surgery in Practice and Science Colon cancer Lymph nodes Lymph node harvest Lymphadenectomy Survival Colorectal Surgery |
| title | Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis |
| title_full | Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis |
| title_fullStr | Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis |
| title_short | Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis |
| title_sort | lymph node harvest as a predictor of survival for colon cancer a systematic review and meta analysis |
| topic | Colon cancer Lymph nodes Lymph node harvest Lymphadenectomy Survival Colorectal Surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2666262023000360 |
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