The LEM-ESCRT toolkit: Repair and maintenance of the nucleus
The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the macromolecular nuclear pore complexes.Loss of nuclea...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.989217/full |
| _version_ | 1828113003504992256 |
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| author | Sapan Borah Karthigeyan Dhanasekaran Santosh Kumar |
| author_facet | Sapan Borah Karthigeyan Dhanasekaran Santosh Kumar |
| author_sort | Sapan Borah |
| collection | DOAJ |
| description | The eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the macromolecular nuclear pore complexes.Loss of nuclear compartmentalization due to defects in NPC function and NE integrity are tied to neurological and ageing disorders like Alzheimer’s, viral pathogenesis, immune disorders, and cancer progression.Recent work implicates inner-nuclear membrane proteins of the conserved LEM domain family and the ESCRT machinery in NE reformation during cell division and NE repair upon rupture in migrating cancer cells, and generating seals over defective NPCs. In this review, we discuss the recent in-roads made into defining the molecular mechanisms and biochemical networks engaged by LEM and many other integral inner nuclear membrane proteins to preserve the nuclear barrier. |
| first_indexed | 2024-04-11T11:59:37Z |
| format | Article |
| id | doaj.art-5e82341b7799454ba60d61a9bd7ae772 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T11:59:37Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-5e82341b7799454ba60d61a9bd7ae7722022-12-22T04:24:57ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-09-011010.3389/fcell.2022.989217989217The LEM-ESCRT toolkit: Repair and maintenance of the nucleusSapan Borah0Karthigeyan Dhanasekaran1Santosh Kumar2National Institute of Immunohaematology, Mumbai, Maharashtra, IndiaRegional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, IndiaNational Centre for Cell Science, Pune, Maharashtra, IndiaThe eukaryotic genome is enclosed in a nuclear envelope that protects it from potentially damaging cellular activities and physically segregates transcription and translation.Transport across the NE is highly regulated and occurs primarily via the macromolecular nuclear pore complexes.Loss of nuclear compartmentalization due to defects in NPC function and NE integrity are tied to neurological and ageing disorders like Alzheimer’s, viral pathogenesis, immune disorders, and cancer progression.Recent work implicates inner-nuclear membrane proteins of the conserved LEM domain family and the ESCRT machinery in NE reformation during cell division and NE repair upon rupture in migrating cancer cells, and generating seals over defective NPCs. In this review, we discuss the recent in-roads made into defining the molecular mechanisms and biochemical networks engaged by LEM and many other integral inner nuclear membrane proteins to preserve the nuclear barrier.https://www.frontiersin.org/articles/10.3389/fcell.2022.989217/fullNPClemESCRTnuclear envelopeNEBDNUP |
| spellingShingle | Sapan Borah Karthigeyan Dhanasekaran Santosh Kumar The LEM-ESCRT toolkit: Repair and maintenance of the nucleus Frontiers in Cell and Developmental Biology NPC lem ESCRT nuclear envelope NEBD NUP |
| title | The LEM-ESCRT toolkit: Repair and maintenance of the nucleus |
| title_full | The LEM-ESCRT toolkit: Repair and maintenance of the nucleus |
| title_fullStr | The LEM-ESCRT toolkit: Repair and maintenance of the nucleus |
| title_full_unstemmed | The LEM-ESCRT toolkit: Repair and maintenance of the nucleus |
| title_short | The LEM-ESCRT toolkit: Repair and maintenance of the nucleus |
| title_sort | lem escrt toolkit repair and maintenance of the nucleus |
| topic | NPC lem ESCRT nuclear envelope NEBD NUP |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.989217/full |
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