MT1A single Nucleotide Polymorphism and Blood Mercury Levels
Introduction: The risk factors for the metallothionein (MT) polymorphism in concentrations of heavy metals, especially mercury, in the blood are subject to several confounding factors, including differences in the ethnicity of the population analyzed, the sample size, and the type of the studied env...
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| Format: | Article |
| Language: | English |
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Zabansaraye Parsian Novin Mehr Institute
2022-09-01
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| Series: | Journal of Current Oncology and Medical Sciences |
| Subjects: | |
| Online Access: | http://submission.journalofcoms.com/index.php/JCOMS/article/view/69 |
| _version_ | 1827981548847104000 |
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| author | Maryam Salacheh Amir Jalali Javad Babaei Hamid Galehdari Amal Saki |
| author_facet | Maryam Salacheh Amir Jalali Javad Babaei Hamid Galehdari Amal Saki |
| author_sort | Maryam Salacheh |
| collection | DOAJ |
| description | Introduction: The risk factors for the metallothionein (MT) polymorphism in concentrations of heavy metals, especially mercury, in the blood are subject to several confounding factors, including differences in the ethnicity of the population analyzed, the sample size, and the type of the studied environment heavy metals to which population is exposed. This study aimed to investigate the effects of the MT1A (A>G) and MT1A (C>G) single nucleotide polymorphisms (SNPs) on blood mercury levels in the city of Ahvaz (located in southwest Iran).
Materials and Methods: 300 unexposed (control group) and 150 exposed (case group) were included. DNA extraction, PCR-RFLP and DNA sequencing were performed, and blood mercury levels were determined by AAS method with DMA-80.
Results: Blood mercury levels in the case group were higher than those in the control group (p-value <0>G), with MT1A (C>G) polymorphism and P-values of blood mercury levels of 0.69, 0.44, and 0.59. 0.56 for the case and control groups, respectively. Results showed that these two SNPs were not associated with mercury-induced toxicity in the case group despite high blood mercury levels and exposure.
Conclusion: In conclusion, this takes look shows that MT1A (A>G) and MT1A (C>G) polymorphisms aren't related to susceptibility to excessive blood mercury attention in individuals. |
| first_indexed | 2024-04-09T22:10:35Z |
| format | Article |
| id | doaj.art-5e831b307ced45bbba368abcf003167f |
| institution | Directory Open Access Journal |
| issn | 2783-3127 |
| language | English |
| last_indexed | 2024-04-09T22:10:35Z |
| publishDate | 2022-09-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj.art-5e831b307ced45bbba368abcf003167f2023-03-23T12:01:43ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272022-09-0123249256MT1A single Nucleotide Polymorphism and Blood Mercury LevelsMaryam Salacheh 0Amir Jalali 1Javad Babaei 2Hamid Galehdari 3Amal Saki 4Department of Toxicology, School of Pharmacy and Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Applied Cellular Sciences and Tissue Engineering, Langroud School of Allied Medical Sciences and Medical Biotechnology Center, Guilan University of Medical Sciences, Rasht, IranDepartment of Toxicology, School of Pharmacy and Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Genetics, School of Sciences, Chamran University, Ahvaz, IranDepartment of Statistics, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranIntroduction: The risk factors for the metallothionein (MT) polymorphism in concentrations of heavy metals, especially mercury, in the blood are subject to several confounding factors, including differences in the ethnicity of the population analyzed, the sample size, and the type of the studied environment heavy metals to which population is exposed. This study aimed to investigate the effects of the MT1A (A>G) and MT1A (C>G) single nucleotide polymorphisms (SNPs) on blood mercury levels in the city of Ahvaz (located in southwest Iran). Materials and Methods: 300 unexposed (control group) and 150 exposed (case group) were included. DNA extraction, PCR-RFLP and DNA sequencing were performed, and blood mercury levels were determined by AAS method with DMA-80. Results: Blood mercury levels in the case group were higher than those in the control group (p-value <0>G), with MT1A (C>G) polymorphism and P-values of blood mercury levels of 0.69, 0.44, and 0.59. 0.56 for the case and control groups, respectively. Results showed that these two SNPs were not associated with mercury-induced toxicity in the case group despite high blood mercury levels and exposure. Conclusion: In conclusion, this takes look shows that MT1A (A>G) and MT1A (C>G) polymorphisms aren't related to susceptibility to excessive blood mercury attention in individuals.http://submission.journalofcoms.com/index.php/JCOMS/article/view/69mercurymetallothioneinmt1a (a>g)mt1a(c>g)iranian population |
| spellingShingle | Maryam Salacheh Amir Jalali Javad Babaei Hamid Galehdari Amal Saki MT1A single Nucleotide Polymorphism and Blood Mercury Levels Journal of Current Oncology and Medical Sciences mercury metallothionein mt1a (a>g) mt1a(c>g) iranian population |
| title | MT1A single Nucleotide Polymorphism and Blood Mercury Levels |
| title_full | MT1A single Nucleotide Polymorphism and Blood Mercury Levels |
| title_fullStr | MT1A single Nucleotide Polymorphism and Blood Mercury Levels |
| title_full_unstemmed | MT1A single Nucleotide Polymorphism and Blood Mercury Levels |
| title_short | MT1A single Nucleotide Polymorphism and Blood Mercury Levels |
| title_sort | mt1a single nucleotide polymorphism and blood mercury levels |
| topic | mercury metallothionein mt1a (a>g) mt1a(c>g) iranian population |
| url | http://submission.journalofcoms.com/index.php/JCOMS/article/view/69 |
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