DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness
Tumor hypoxia is associated with resistance to treatment, aggressive growth, metastatic dissemination, and poor clinical outcome in many cancer types. The potential of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the extent of hypoxia in tumors has been investigated in se...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/7/1979 |
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| author | Jon-Vidar Gaustad Anette Hauge Catherine S. Wegner Trude G. Simonsen Kjersti V. Lund Lise Mari K. Hansem Einar K. Rofstad |
| author_facet | Jon-Vidar Gaustad Anette Hauge Catherine S. Wegner Trude G. Simonsen Kjersti V. Lund Lise Mari K. Hansem Einar K. Rofstad |
| author_sort | Jon-Vidar Gaustad |
| collection | DOAJ |
| description | Tumor hypoxia is associated with resistance to treatment, aggressive growth, metastatic dissemination, and poor clinical outcome in many cancer types. The potential of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the extent of hypoxia in tumors has been investigated in several studies in our laboratory. Cervical carcinoma, melanoma, and pancreatic ductal adenocarcinoma (PDAC) xenografts have been used as models of human cancer, and the transfer rate constant (<i>K</i><sup>trans</sup>) and the extravascular extracellular volume fraction (<i>v</i><sub>e</sub>) have been derived from DCE-MRI data by using Tofts standard pharmacokinetic model and a population-based arterial input function. <i>K</i><sup>trans</sup> was found to reflect naturally occurring and treatment-induced hypoxia when hypoxia was caused by low blood perfusion, radiation responsiveness when radiation resistance was due to hypoxia, and metastatic potential when metastasis was hypoxia-induced. <i>K</i><sup>trans</sup> was also associated with outcome for patients with locally-advanced cervical carcinoma treated with cisplatin-based chemoradiotherapy. Together, the studies imply that DCE-MRI can provide valuable information on the hypoxic status of cervical carcinoma, melanoma, and PDAC. In this communication, we review and discuss the studies and provide some recommendations as to how DCE-MRI data can be analyzed and interpreted to assess tumor hypoxia. |
| first_indexed | 2024-03-10T18:20:47Z |
| format | Article |
| id | doaj.art-5e8345bc3b5b46cc957019070ba32117 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:20:47Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5e8345bc3b5b46cc957019070ba321172023-11-20T07:22:07ZengMDPI AGCancers2072-66942020-07-01127197910.3390/cancers12071979DCE-MRI of Tumor Hypoxia and Hypoxia-Associated AggressivenessJon-Vidar Gaustad0Anette Hauge1Catherine S. Wegner2Trude G. Simonsen3Kjersti V. Lund4Lise Mari K. Hansem5Einar K. Rofstad6Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0310 Oslo, NorwayGroup of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0310 Oslo, NorwayGroup of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0310 Oslo, NorwayGroup of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0310 Oslo, NorwayGroup of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0310 Oslo, NorwayGroup of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0310 Oslo, NorwayGroup of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, 0310 Oslo, NorwayTumor hypoxia is associated with resistance to treatment, aggressive growth, metastatic dissemination, and poor clinical outcome in many cancer types. The potential of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the extent of hypoxia in tumors has been investigated in several studies in our laboratory. Cervical carcinoma, melanoma, and pancreatic ductal adenocarcinoma (PDAC) xenografts have been used as models of human cancer, and the transfer rate constant (<i>K</i><sup>trans</sup>) and the extravascular extracellular volume fraction (<i>v</i><sub>e</sub>) have been derived from DCE-MRI data by using Tofts standard pharmacokinetic model and a population-based arterial input function. <i>K</i><sup>trans</sup> was found to reflect naturally occurring and treatment-induced hypoxia when hypoxia was caused by low blood perfusion, radiation responsiveness when radiation resistance was due to hypoxia, and metastatic potential when metastasis was hypoxia-induced. <i>K</i><sup>trans</sup> was also associated with outcome for patients with locally-advanced cervical carcinoma treated with cisplatin-based chemoradiotherapy. Together, the studies imply that DCE-MRI can provide valuable information on the hypoxic status of cervical carcinoma, melanoma, and PDAC. In this communication, we review and discuss the studies and provide some recommendations as to how DCE-MRI data can be analyzed and interpreted to assess tumor hypoxia.https://www.mdpi.com/2072-6694/12/7/1979tumor hypoxiahypoxia-associated treatment responsehypoxia-induced metastasisDCE-MRIcervical carcinomamelanoma |
| spellingShingle | Jon-Vidar Gaustad Anette Hauge Catherine S. Wegner Trude G. Simonsen Kjersti V. Lund Lise Mari K. Hansem Einar K. Rofstad DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness Cancers tumor hypoxia hypoxia-associated treatment response hypoxia-induced metastasis DCE-MRI cervical carcinoma melanoma |
| title | DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness |
| title_full | DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness |
| title_fullStr | DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness |
| title_full_unstemmed | DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness |
| title_short | DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness |
| title_sort | dce mri of tumor hypoxia and hypoxia associated aggressiveness |
| topic | tumor hypoxia hypoxia-associated treatment response hypoxia-induced metastasis DCE-MRI cervical carcinoma melanoma |
| url | https://www.mdpi.com/2072-6694/12/7/1979 |
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