Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors
Introduction in practice of therapeutic establishments in the RF of antiviral therapy of chronic viral hepatitis in the form of interferon-free schemes led to considerable increase of the frequency of the stable virologic response. Study objective: determination of virologic response predictors in C...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2016-12-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/1466 |
| _version_ | 1797841353153970176 |
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| author | N. I. Geyvandova A. V. Lipov P. V. Koroy A. V. Yagoda S. S. Rogova |
| author_facet | N. I. Geyvandova A. V. Lipov P. V. Koroy A. V. Yagoda S. S. Rogova |
| author_sort | N. I. Geyvandova |
| collection | DOAJ |
| description | Introduction in practice of therapeutic establishments in the RF of antiviral therapy of chronic viral hepatitis in the form of interferon-free schemes led to considerable increase of the frequency of the stable virologic response. Study objective: determination of virologic response predictors in CVHC patients when various therapeutic schemes are used. Materials and methods: Group 1 of CVHC 52 patients with genotype 1 of HCV received standard anti-viral therapy, Group 2 (21 subject) – interferon-free scheme (Viekira Pak+ Ribavirin). Genetic polymorphisms IL-28В rs12979860 (С>Т) and rs8099917 (Т>G) and blood interferon-γ induced protein – IP-10 were determined. Results: standard anti-viral therapy in Group 1 resulted in SVR (sustained viral response) in 29 patients (55.7%). In Group 2 that received Viekira Pak 100% SVR was achieved in spite of more frequent F3 and 4 stage of fibrosis, unsuccessful anti-viral therapy (9 persons), contraindications to IFN-α drugs (6 persons). Unfavorable genotypes IL-28B ТТ (rs12979860) and GG (rs8099917) were associated in Group 1 with lack of SVR, level of IP-10 in patients with SVR was lower than the one in non-respondents. The therapy by Viekira Pak was well tolerated and resulted in SVR despite presence of grave hepatic fibrosis/ cirrhosis, concomitant pathology, unfavourable options of IL-28B, high IP-10 protein levels. Conclusion: choice of optimal anti-viral therapy schemes for each patient with CVHC must be done taken into account all possible predictors, which allows optimizing the therapy and preventing the necessity of repeated therapy. |
| first_indexed | 2024-04-09T16:29:37Z |
| format | Article |
| id | doaj.art-5e835d095ebf4632b748aa9cc38f8b9d |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:29:37Z |
| publishDate | 2016-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-5e835d095ebf4632b748aa9cc38f8b9d2023-04-23T06:57:10ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902016-12-01014687410.21518/2079-701X-2016-14-68-741462Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictorsN. I. Geyvandova0A. V. Lipov1P. V. Koroy2A. V. Yagoda3S. S. Rogova4Stavropol State Medical University of the Ministry of Health of RussiaStavropol State Medical University of the Ministry of Health of RussiaStavropol State Medical University of the Ministry of Health of RussiaStavropol State Medical University of the Ministry of Health of RussiaStavropol State Medical University of the Ministry of Health of RussiaIntroduction in practice of therapeutic establishments in the RF of antiviral therapy of chronic viral hepatitis in the form of interferon-free schemes led to considerable increase of the frequency of the stable virologic response. Study objective: determination of virologic response predictors in CVHC patients when various therapeutic schemes are used. Materials and methods: Group 1 of CVHC 52 patients with genotype 1 of HCV received standard anti-viral therapy, Group 2 (21 subject) – interferon-free scheme (Viekira Pak+ Ribavirin). Genetic polymorphisms IL-28В rs12979860 (С>Т) and rs8099917 (Т>G) and blood interferon-γ induced protein – IP-10 were determined. Results: standard anti-viral therapy in Group 1 resulted in SVR (sustained viral response) in 29 patients (55.7%). In Group 2 that received Viekira Pak 100% SVR was achieved in spite of more frequent F3 and 4 stage of fibrosis, unsuccessful anti-viral therapy (9 persons), contraindications to IFN-α drugs (6 persons). Unfavorable genotypes IL-28B ТТ (rs12979860) and GG (rs8099917) were associated in Group 1 with lack of SVR, level of IP-10 in patients with SVR was lower than the one in non-respondents. The therapy by Viekira Pak was well tolerated and resulted in SVR despite presence of grave hepatic fibrosis/ cirrhosis, concomitant pathology, unfavourable options of IL-28B, high IP-10 protein levels. Conclusion: choice of optimal anti-viral therapy schemes for each patient with CVHC must be done taken into account all possible predictors, which allows optimizing the therapy and preventing the necessity of repeated therapy.https://www.med-sovet.pro/jour/article/view/1466chronic viral hepatitis canti-viral therapyforecastinginterferon-free drugs |
| spellingShingle | N. I. Geyvandova A. V. Lipov P. V. Koroy A. V. Yagoda S. S. Rogova Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors Медицинский совет chronic viral hepatitis c anti-viral therapy forecasting interferon-free drugs |
| title | Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors |
| title_full | Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors |
| title_fullStr | Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors |
| title_full_unstemmed | Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors |
| title_short | Experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors |
| title_sort | experience of therapy of chronic viral hepatitis c patients with unfavourable response predictors |
| topic | chronic viral hepatitis c anti-viral therapy forecasting interferon-free drugs |
| url | https://www.med-sovet.pro/jour/article/view/1466 |
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