Neutrophils and Close Relatives in the Hypoxic Environment of the Tuberculous Granuloma: New Avenues for Host-Directed Therapies?

Neutrophils and Close Relatives in the Hypoxic Environment of the Tuberculous Granuloma: New Avenues for Host-Directed Therapies?

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is one of the most prevalent lung infections of humans and kills ~1.7 million people each year. TB pathophysiology is complex with a central role played by granuloma where a delicate balance takes place to both constrain bacilli and preve...

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Bibliographic Details
Main Authors: Aude Remot, Emilie Doz, Nathalie Winter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
neutrophils
Mycobacterium tuberculosis
granuloma
lung
HIF
hypoxia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00417/full

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