Histone Modification of Colorectal Cancer by Natural Products
Natural products play important roles in the pathogenesis of many human malignancies, including colorectal cancer, and can act as a gene regulator in many cancers. They regulate malignant cell growth through many cellular signal pathways, including Rac family small GTPase 1 (RAC1)/PI3K/AKT (α-serine...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/8/1095 |
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| author | Zijun Geng Meiqi Chen Qixuan Yu Shuoxi Guo Tianli Chen Da Liu |
| author_facet | Zijun Geng Meiqi Chen Qixuan Yu Shuoxi Guo Tianli Chen Da Liu |
| author_sort | Zijun Geng |
| collection | DOAJ |
| description | Natural products play important roles in the pathogenesis of many human malignancies, including colorectal cancer, and can act as a gene regulator in many cancers. They regulate malignant cell growth through many cellular signal pathways, including Rac family small GTPase 1 (RAC1)/PI3K/AKT (α-serine/threonine-protein kinase), mitogen-activated protein kinase (MAPK), Wnt/β-catenin pathway, transforming growth factor-β (TGF-β), Janus kinase and signal transducer and activator of transcription (JAK-STAT), nuclear factor kappa-B (NF-κB), the Notch pathway, Hippo pathway, and Hedgehog pathway. In this review, we describe the epigenetic roles of several natural products, e.g., platycodin D (PD), ginsenoside Rd, tretinoin, Rutin, curcumin, clove extract, betulinic acid, resveratrol, and curcumin, in colorectal cancer, including their impact on colorectal cancer cell proliferation, apoptosis, invasion, migration, and anti-chemotherapeutic resistance. The aim is to illustrate the epigenetic mechanisms of action of natural products in cancer prevention and treatment, and to provide (1) a theoretical basis for the study of the role of epigenetics in influencing colorectal cancer; (2) new directions for studying the occurrence, development, and prognosis of colorectal cancer; and (3) new targets for treating and preventing colorectal cancer. |
| first_indexed | 2024-03-10T23:39:30Z |
| format | Article |
| id | doaj.art-5e8606479bd742b4a672959e22f82b4f |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T23:39:30Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-5e8606479bd742b4a672959e22f82b4f2023-11-19T02:33:49ZengMDPI AGPharmaceuticals1424-82472023-08-01168109510.3390/ph16081095Histone Modification of Colorectal Cancer by Natural ProductsZijun Geng0Meiqi Chen1Qixuan Yu2Shuoxi Guo3Tianli Chen4Da Liu5School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaNatural products play important roles in the pathogenesis of many human malignancies, including colorectal cancer, and can act as a gene regulator in many cancers. They regulate malignant cell growth through many cellular signal pathways, including Rac family small GTPase 1 (RAC1)/PI3K/AKT (α-serine/threonine-protein kinase), mitogen-activated protein kinase (MAPK), Wnt/β-catenin pathway, transforming growth factor-β (TGF-β), Janus kinase and signal transducer and activator of transcription (JAK-STAT), nuclear factor kappa-B (NF-κB), the Notch pathway, Hippo pathway, and Hedgehog pathway. In this review, we describe the epigenetic roles of several natural products, e.g., platycodin D (PD), ginsenoside Rd, tretinoin, Rutin, curcumin, clove extract, betulinic acid, resveratrol, and curcumin, in colorectal cancer, including their impact on colorectal cancer cell proliferation, apoptosis, invasion, migration, and anti-chemotherapeutic resistance. The aim is to illustrate the epigenetic mechanisms of action of natural products in cancer prevention and treatment, and to provide (1) a theoretical basis for the study of the role of epigenetics in influencing colorectal cancer; (2) new directions for studying the occurrence, development, and prognosis of colorectal cancer; and (3) new targets for treating and preventing colorectal cancer.https://www.mdpi.com/1424-8247/16/8/1095epigeneticscolorectal cancerhistone modificationhistone deacetylation and acetylationhistone phosphorylationhistone methylation and demethylation |
| spellingShingle | Zijun Geng Meiqi Chen Qixuan Yu Shuoxi Guo Tianli Chen Da Liu Histone Modification of Colorectal Cancer by Natural Products Pharmaceuticals epigenetics colorectal cancer histone modification histone deacetylation and acetylation histone phosphorylation histone methylation and demethylation |
| title | Histone Modification of Colorectal Cancer by Natural Products |
| title_full | Histone Modification of Colorectal Cancer by Natural Products |
| title_fullStr | Histone Modification of Colorectal Cancer by Natural Products |
| title_full_unstemmed | Histone Modification of Colorectal Cancer by Natural Products |
| title_short | Histone Modification of Colorectal Cancer by Natural Products |
| title_sort | histone modification of colorectal cancer by natural products |
| topic | epigenetics colorectal cancer histone modification histone deacetylation and acetylation histone phosphorylation histone methylation and demethylation |
| url | https://www.mdpi.com/1424-8247/16/8/1095 |
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