Vitamin D3 Exerts Beneficial Effects on C2C12 Myotubes through Activation of the Vitamin D Receptor (VDR)/Sirtuins (SIRT)1/3 Axis

Vitamin D3 Exerts Beneficial Effects on C2C12 Myotubes through Activation of the Vitamin D Receptor (VDR)/Sirtuins (SIRT)1/3 Axis

The onset of sarcopenia is associated with a decline in vitamin D receptor (VDR) expression, wherein reduced VDR levels contribute to muscle atrophy, while heightened expression promotes muscle hypertrophy. Like VDR, the age-related decline in protein deacetylase sirtuin (SIRT) expression is linked...

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Bibliographic Details
Main Authors: Nurul Fatihah Talib, Zunshu Zhu, Kyoung-Soo Kim
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Nutrients
Subjects:
vitamin D
vitamin D receptor (VDR)
sirtuins
sarcopenia
muscle atrophy
mitochondrial biogenesis
Online Access:https://www.mdpi.com/2072-6643/15/22/4714

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