Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases
There is growing evidence that mesenchymal stem cell-derived extracellular vesicles and exosomes can significantly improve the curative effect of oxidative stress-related diseases. Mesenchymal stem cell extracellular vesicles and exosomes (MSC-EVs and MSC-Exos) are rich in bioactive molecules and ha...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238789/full |
| _version_ | 1797743103550947328 |
|---|---|
| author | Wenwen Zhang Wenwen Zhang Tingyu Wang Tingyu Wang Yuanye Xue Yuanye Xue Bingbing Zhan Zengjie Lai Wenjie Huang Xinsheng Peng Xinsheng Peng Yanfang Zhou Yanfang Zhou |
| author_facet | Wenwen Zhang Wenwen Zhang Tingyu Wang Tingyu Wang Yuanye Xue Yuanye Xue Bingbing Zhan Zengjie Lai Wenjie Huang Xinsheng Peng Xinsheng Peng Yanfang Zhou Yanfang Zhou |
| author_sort | Wenwen Zhang |
| collection | DOAJ |
| description | There is growing evidence that mesenchymal stem cell-derived extracellular vesicles and exosomes can significantly improve the curative effect of oxidative stress-related diseases. Mesenchymal stem cell extracellular vesicles and exosomes (MSC-EVs and MSC-Exos) are rich in bioactive molecules and have many biological regulatory functions. In this review, we describe how MSC-EVs and MSC-Exos reduce the related markers of oxidative stress and inflammation in various systemic diseases, and the molecular mechanism of MSC-EVs and MSC-Exos in treating apoptosis and vascular injury induced by oxidative stress. The results of a large number of experimental studies have shown that both local and systemic administration can effectively inhibit the oxidative stress response in diseases and promote the survival and regeneration of damaged parenchymal cells. The mRNA and miRNAs in MSC-EVs and MSC-Exos are the most important bioactive molecules in disease treatment, which can inhibit the apoptosis, necrosis and oxidative stress of lung, heart, kidney, liver, bone, skin and other cells, and promote their survive and regenerate. |
| first_indexed | 2024-03-12T14:50:43Z |
| format | Article |
| id | doaj.art-5e8c2a307817495a916f3f885a38c8e8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T14:50:43Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5e8c2a307817495a916f3f885a38c8e82023-08-15T16:21:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-08-011410.3389/fimmu.2023.12387891238789Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseasesWenwen Zhang0Wenwen Zhang1Tingyu Wang2Tingyu Wang3Yuanye Xue4Yuanye Xue5Bingbing Zhan6Zengjie Lai7Wenjie Huang8Xinsheng Peng9Xinsheng Peng10Yanfang Zhou11Yanfang Zhou12The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, Guangdong, ChinaDepartment of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, ChinaThe First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, Guangdong, ChinaDepartment of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, ChinaThe First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, Guangdong, ChinaDepartment of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, ChinaSchool of Pharmaceutical Sciences, Guangdong Medical University, Dongguan, ChinaThe Second Clinical Medical College of Guangdong Medical University, Dongguan, ChinaSchool of Medical Technology, Guangdong Medical University, Dongguan, ChinaBiomedical Innovation Center, Guangdong Medical University, Dongguan, ChinaInstitute of Marine Medicine, Guangdong Medical University, Zhanjiang, ChinaThe First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, Guangdong, ChinaDepartment of Pathophysiology, Guangdong Medical University, Dongguan, Guangdong, ChinaThere is growing evidence that mesenchymal stem cell-derived extracellular vesicles and exosomes can significantly improve the curative effect of oxidative stress-related diseases. Mesenchymal stem cell extracellular vesicles and exosomes (MSC-EVs and MSC-Exos) are rich in bioactive molecules and have many biological regulatory functions. In this review, we describe how MSC-EVs and MSC-Exos reduce the related markers of oxidative stress and inflammation in various systemic diseases, and the molecular mechanism of MSC-EVs and MSC-Exos in treating apoptosis and vascular injury induced by oxidative stress. The results of a large number of experimental studies have shown that both local and systemic administration can effectively inhibit the oxidative stress response in diseases and promote the survival and regeneration of damaged parenchymal cells. The mRNA and miRNAs in MSC-EVs and MSC-Exos are the most important bioactive molecules in disease treatment, which can inhibit the apoptosis, necrosis and oxidative stress of lung, heart, kidney, liver, bone, skin and other cells, and promote their survive and regenerate.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238789/fullmesenchymal stem cellsextracellular vesiclesexosomesoxidative stressinflammationcell proliferation |
| spellingShingle | Wenwen Zhang Wenwen Zhang Tingyu Wang Tingyu Wang Yuanye Xue Yuanye Xue Bingbing Zhan Zengjie Lai Wenjie Huang Xinsheng Peng Xinsheng Peng Yanfang Zhou Yanfang Zhou Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases Frontiers in Immunology mesenchymal stem cells extracellular vesicles exosomes oxidative stress inflammation cell proliferation |
| title | Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases |
| title_full | Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases |
| title_fullStr | Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases |
| title_full_unstemmed | Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases |
| title_short | Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases |
| title_sort | research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress related diseases |
| topic | mesenchymal stem cells extracellular vesicles exosomes oxidative stress inflammation cell proliferation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238789/full |
| work_keys_str_mv | AT wenwenzhang researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT wenwenzhang researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT tingyuwang researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT tingyuwang researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT yuanyexue researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT yuanyexue researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT bingbingzhan researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT zengjielai researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT wenjiehuang researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT xinshengpeng researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT xinshengpeng researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT yanfangzhou researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases AT yanfangzhou researchprogressofextracellularvesiclesandexosomesderivedfrommesenchymalstemcellsinthetreatmentofoxidativestressrelateddiseases |