TNF-α Suppresses Apelin Receptor Expression in Mouse Quadriceps Femoris-Derived Cells

TNF-α Suppresses Apelin Receptor Expression in Mouse Quadriceps Femoris-Derived Cells

Expression of the apelin receptor, APJ, in skeletal muscle (SM) is known to decrease with age, but the underlying mechanism remains unclear. Increased tumor necrosis factor (TNF)-α levels are observed in SM with age and are associated with muscle atrophy. To investigate the possible interconnection...

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Bibliographic Details
Main Authors: Tomohisa Koyama, Kentaro Uchida, Makoto Itakura, Masayuki Miyagi, Ryo Tazawa, Gen Inoue, Kensuke Fukushima, Yoshihisa Ohashi, Ayumi Tsukada, Masashi Takaso
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Current Issues in Molecular Biology
Subjects:
apelin receptor (APJ)
TNF-α
skeletal muscle
aging
Online Access:https://www.mdpi.com/1467-3045/44/7/217

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