Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI?
Background: The aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index (BMI) from the biochemical markers related to metabolism and the Apa I polymorphism in IGF-II gene.Methods: A total of 300 children were selected randomly from the Mac...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2013-05-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | http://ijph.tums.ac.ir/index.php/IJPH/article/view/3195/2142 |
| _version_ | 1818610668277858304 |
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| author | Unqing Wu Jingchao Ren Yuyan Li Yinjie Wu Ersheng Gao |
| author_facet | Unqing Wu Jingchao Ren Yuyan Li Yinjie Wu Ersheng Gao |
| author_sort | Unqing Wu |
| collection | DOAJ |
| description | Background: The aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index (BMI) from the biochemical markers related to metabolism and the Apa I polymorphism in IGF-II gene.Methods: A total of 300 children were selected randomly from the Macrosomia Birth Cohort in Wuxi, China. The height and weight were measured and blood samples were collected. Plasma concentrations of 8 biochemical markers were detected. Apa I polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: Biochemical markers were detected for 296 subjects and 271 subjects were genotyped for the Apa I polymorphism. No association was found between birth weight and 8 biochemical markers. In boys, the BMIs of AA, AG and GG genotypes were 16.10 ± 2.24 kg/m2, 17.40 ± 3.20 kg/m2, 17.65 ± 2.66 kg/m2. And there was statistical difference among the three genotypes. But in girls, there was no statistical difference. The birth weights of AA, AG and GG genotypes were 3751.13 ± 492.43 g, 3734.00 ± 456.88 g, 3782.00 ± 461.78 g. And there was no statistical difference among the three genotypes.Conclusion: Biochemical markers are not associated with birth weight. Apa I polymorphism may be related to childhood BMI, but it may be not associated with birth weight. Therefore, biochemical markers and Apa I polymorphism might not play a role in the association of birth weight and BMI. |
| first_indexed | 2024-12-16T15:18:05Z |
| format | Article |
| id | doaj.art-5e9077ea8cc24a05b15dfc549acb3e1a |
| institution | Directory Open Access Journal |
| issn | 2251-6085 |
| language | English |
| last_indexed | 2024-12-16T15:18:05Z |
| publishDate | 2013-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-5e9077ea8cc24a05b15dfc549acb3e1a2022-12-21T22:26:44ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852013-05-01425480488Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI?Unqing WuJingchao RenYuyan LiYinjie WuErsheng GaoBackground: The aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index (BMI) from the biochemical markers related to metabolism and the Apa I polymorphism in IGF-II gene.Methods: A total of 300 children were selected randomly from the Macrosomia Birth Cohort in Wuxi, China. The height and weight were measured and blood samples were collected. Plasma concentrations of 8 biochemical markers were detected. Apa I polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: Biochemical markers were detected for 296 subjects and 271 subjects were genotyped for the Apa I polymorphism. No association was found between birth weight and 8 biochemical markers. In boys, the BMIs of AA, AG and GG genotypes were 16.10 ± 2.24 kg/m2, 17.40 ± 3.20 kg/m2, 17.65 ± 2.66 kg/m2. And there was statistical difference among the three genotypes. But in girls, there was no statistical difference. The birth weights of AA, AG and GG genotypes were 3751.13 ± 492.43 g, 3734.00 ± 456.88 g, 3782.00 ± 461.78 g. And there was no statistical difference among the three genotypes.Conclusion: Biochemical markers are not associated with birth weight. Apa I polymorphism may be related to childhood BMI, but it may be not associated with birth weight. Therefore, biochemical markers and Apa I polymorphism might not play a role in the association of birth weight and BMI.http://ijph.tums.ac.ir/index.php/IJPH/article/view/3195/2142Biochemical MarkerApa I PolymorphismBirth WeightBMIIGF-II gene |
| spellingShingle | Unqing Wu Jingchao Ren Yuyan Li Yinjie Wu Ersheng Gao Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI? Iranian Journal of Public Health Biochemical Marker Apa I Polymorphism Birth Weight BMI IGF-II gene |
| title | Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI? |
| title_full | Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI? |
| title_fullStr | Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI? |
| title_full_unstemmed | Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI? |
| title_short | Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI? |
| title_sort | do biochemical markers and apa i polymorphism in igf ii gene play a role in the association of birth weight and later bmi |
| topic | Biochemical Marker Apa I Polymorphism Birth Weight BMI IGF-II gene |
| url | http://ijph.tums.ac.ir/index.php/IJPH/article/view/3195/2142 |
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