Highlights on the Luspatercept Treatment in Thalassemia

Highlights on the Luspatercept Treatment in Thalassemia

Luspatercept has been shown to act as a ligand trap, selectively suppressing the deleterious effects of GDF11 that blocks terminal erythroid maturation, restoring normal erythroid differentiation and improving anemia in animal models of β-thalassemia. Effective doses of luspatercept achieved hemoglo...

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Bibliographic Details
Main Author:	Yesim Aydinok
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Thalassemia Reports
Subjects:	luspatercept transfusion-dependent thalassemia non-transfusion-dependent thalassemia ineffective erythropoiesis beta thalassemia HbE/beta thalassemia
Online Access:	https://www.mdpi.com/2039-4365/13/1/8

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