Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy Alone
We compared the cumulative incidence of local recurrence in young patients (≤40 years) with breast cancer between breast conserving therapy (BCT) and mastectomy alone. Among 428 women with early-stage breast cancer who were treated between 2001 and 2012, 311 underwent BCT and 117 underwent mastectom...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/9/2150 |
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| author | Dang Van Nguyen Sang-Won Kim Young-Taek Oh O Kyu Noh Yongsik Jung Mison Chun Dae Sung Yoon |
| author_facet | Dang Van Nguyen Sang-Won Kim Young-Taek Oh O Kyu Noh Yongsik Jung Mison Chun Dae Sung Yoon |
| author_sort | Dang Van Nguyen |
| collection | DOAJ |
| description | We compared the cumulative incidence of local recurrence in young patients (≤40 years) with breast cancer between breast conserving therapy (BCT) and mastectomy alone. Among 428 women with early-stage breast cancer who were treated between 2001 and 2012, 311 underwent BCT and 117 underwent mastectomy alone. Adjuvant systemic treatments were administered to 409 patients (95.6%). We compared the cumulative incidence of LR and survival rates between two groups. During a median follow-up period of 91 months, the 10-year cumulative incidence of LR was 9.3% (median interval of 36.5 months from surgery). Patients treated with BCT tended to have a higher risk for local recurrence (11.1% for BCT vs. 4.1% for mastectomy alone, <i>p</i> = 0.078). All patients with isolated LR after BCT (<i>n</i> = 23) underwent salvage mastectomy followed by systemic treatments. The 5-year distant metastasis-free survival and overall survival of patients with isolated LR after BCT were 44.2% and 82.2%, respectively. The BCT group exhibited an approximately 2.5-fold higher risk of LR than mastectomy alone group. Patients with isolated LR after BCT showed poor prognosis despite undergoing aggressive salvage treatments. The development of novel treatments should be investigated to reduce LR for improving prognosis and preserving cosmetic outcomes in young women. |
| first_indexed | 2024-03-10T11:49:06Z |
| format | Article |
| id | doaj.art-5e94b76334654b23a3c86c5ab38b3874 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:49:06Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5e94b76334654b23a3c86c5ab38b38742023-11-21T17:48:49ZengMDPI AGCancers2072-66942021-04-01139215010.3390/cancers13092150Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy AloneDang Van Nguyen0Sang-Won Kim1Young-Taek Oh2O Kyu Noh3Yongsik Jung4Mison Chun5Dae Sung Yoon6Department of Oncology, Hanoi Medical University, Hanoi 116001, VietnamDepartment of Radiation Oncology, Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon 35365, KoreaDepartment of Radiation Oncology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Radiation Oncology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Surgery, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Radiation Oncology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Surgery, Konyang University College of Medicine, Daejeon 35365, KoreaWe compared the cumulative incidence of local recurrence in young patients (≤40 years) with breast cancer between breast conserving therapy (BCT) and mastectomy alone. Among 428 women with early-stage breast cancer who were treated between 2001 and 2012, 311 underwent BCT and 117 underwent mastectomy alone. Adjuvant systemic treatments were administered to 409 patients (95.6%). We compared the cumulative incidence of LR and survival rates between two groups. During a median follow-up period of 91 months, the 10-year cumulative incidence of LR was 9.3% (median interval of 36.5 months from surgery). Patients treated with BCT tended to have a higher risk for local recurrence (11.1% for BCT vs. 4.1% for mastectomy alone, <i>p</i> = 0.078). All patients with isolated LR after BCT (<i>n</i> = 23) underwent salvage mastectomy followed by systemic treatments. The 5-year distant metastasis-free survival and overall survival of patients with isolated LR after BCT were 44.2% and 82.2%, respectively. The BCT group exhibited an approximately 2.5-fold higher risk of LR than mastectomy alone group. Patients with isolated LR after BCT showed poor prognosis despite undergoing aggressive salvage treatments. The development of novel treatments should be investigated to reduce LR for improving prognosis and preserving cosmetic outcomes in young women.https://www.mdpi.com/2072-6694/13/9/2150breast cancerbreast conservation therapytotal mastectomyyoung womenlocal recurrence |
| spellingShingle | Dang Van Nguyen Sang-Won Kim Young-Taek Oh O Kyu Noh Yongsik Jung Mison Chun Dae Sung Yoon Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy Alone Cancers breast cancer breast conservation therapy total mastectomy young women local recurrence |
| title | Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy Alone |
| title_full | Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy Alone |
| title_fullStr | Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy Alone |
| title_full_unstemmed | Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy Alone |
| title_short | Local Recurrence in Young Women with Breast Cancer: Breast Conserving Therapy vs. Mastectomy Alone |
| title_sort | local recurrence in young women with breast cancer breast conserving therapy vs mastectomy alone |
| topic | breast cancer breast conservation therapy total mastectomy young women local recurrence |
| url | https://www.mdpi.com/2072-6694/13/9/2150 |
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