The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease
Background and Objectives: Patients with nonobstructive coronary artery disease (NOCAD) have an increased risk of cardiovascular events (CVEs) compared to that in individuals with normal or near-normal coronary arteries (NNCAs) and even a similar risk to that in individuals with obstructive coronary...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2021-01-01
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| Series: | Cardiology Plus |
| Subjects: | |
| Online Access: | http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2021;volume=6;issue=3;spage=166;epage=173;aulast=Zhang |
| _version_ | 1797991343837937664 |
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| author | Hui-Wen Zhang Yuan-Lin Guo Cheng-Gang Zhu Na-Qiong Wu Ying Gao Qian Dong Jing Sun Jian-Jun Li |
| author_facet | Hui-Wen Zhang Yuan-Lin Guo Cheng-Gang Zhu Na-Qiong Wu Ying Gao Qian Dong Jing Sun Jian-Jun Li |
| author_sort | Hui-Wen Zhang |
| collection | DOAJ |
| description | Background and Objectives: Patients with nonobstructive coronary artery disease (NOCAD) have an increased risk of cardiovascular events (CVEs) compared to that in individuals with normal or near-normal coronary arteries (NNCAs) and even a similar risk to that in individuals with obstructive coronary artery disease (OCAD). However, the predictors for a worse outcome in patients with NOCAD are not fully determined. This study aimed to investigate the association of high-sensitive C-reactive protein (hs-CRP) and CVEs in patients with NOCAD. Materials and Methods: In total, 4662 patients with coronary artery angiography were enrolled and followed up for CVE. Patients were classified as having NNCA (<20% stenosis, n = 698, 15.0%), NOCAD (20%–49% stenosis, n = 639, 14.3%), and OCAD (≥50% stenosis, n = 3325, 70.7%) and then further subdivided into three groups based on their baseline hs-CRP level (<1, 1–3, and >3 mg/L). Proportional hazards models were used to assess the risk of CVEs. Results: Over an average 13403 person-year follow-up, 338 patients experienced CVEs. Patients with NOCAD and OCAD had a higher rate of CVE than those with NNCA (P < 0.05). The CVE risk was significantly higher in NOCAD (hazard ratio [HR]: 2.31, 95% confidence interval [CI]: 1.30–4.01, P = 0.004) and OCAD (HR: 3.09, 95% CI: 1.88–5.07, P < 0.001) patients than in NNCA patients. Moreover, elevated hs-CRP levels were associated with an incremental rate of CVE (P < 0.05). Conclusions: Patients with NOCAD had worse outcomes and elevated hs-CRP levels were positively associated with CVEs, which potentially helps assess risk in NOCAD patients. |
| first_indexed | 2024-04-11T08:50:41Z |
| format | Article |
| id | doaj.art-5e95283bcd0d4b73b08e4628eba4e07c |
| institution | Directory Open Access Journal |
| issn | 2470-7511 2470-752X |
| language | English |
| last_indexed | 2024-04-11T08:50:41Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Plus |
| spelling | doaj.art-5e95283bcd0d4b73b08e4628eba4e07c2022-12-22T04:33:35ZengWolters Kluwer Health/LWWCardiology Plus2470-75112470-752X2021-01-016316617310.4103/2470-7511.327240The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery diseaseHui-Wen ZhangYuan-Lin GuoCheng-Gang ZhuNa-Qiong WuYing GaoQian DongJing SunJian-Jun LiBackground and Objectives: Patients with nonobstructive coronary artery disease (NOCAD) have an increased risk of cardiovascular events (CVEs) compared to that in individuals with normal or near-normal coronary arteries (NNCAs) and even a similar risk to that in individuals with obstructive coronary artery disease (OCAD). However, the predictors for a worse outcome in patients with NOCAD are not fully determined. This study aimed to investigate the association of high-sensitive C-reactive protein (hs-CRP) and CVEs in patients with NOCAD. Materials and Methods: In total, 4662 patients with coronary artery angiography were enrolled and followed up for CVE. Patients were classified as having NNCA (<20% stenosis, n = 698, 15.0%), NOCAD (20%–49% stenosis, n = 639, 14.3%), and OCAD (≥50% stenosis, n = 3325, 70.7%) and then further subdivided into three groups based on their baseline hs-CRP level (<1, 1–3, and >3 mg/L). Proportional hazards models were used to assess the risk of CVEs. Results: Over an average 13403 person-year follow-up, 338 patients experienced CVEs. Patients with NOCAD and OCAD had a higher rate of CVE than those with NNCA (P < 0.05). The CVE risk was significantly higher in NOCAD (hazard ratio [HR]: 2.31, 95% confidence interval [CI]: 1.30–4.01, P = 0.004) and OCAD (HR: 3.09, 95% CI: 1.88–5.07, P < 0.001) patients than in NNCA patients. Moreover, elevated hs-CRP levels were associated with an incremental rate of CVE (P < 0.05). Conclusions: Patients with NOCAD had worse outcomes and elevated hs-CRP levels were positively associated with CVEs, which potentially helps assess risk in NOCAD patients.http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2021;volume=6;issue=3;spage=166;epage=173;aulast=Zhangcardiovascular events; high-sensitive c-reactive protein; nonobstructive coronary artery disease |
| spellingShingle | Hui-Wen Zhang Yuan-Lin Guo Cheng-Gang Zhu Na-Qiong Wu Ying Gao Qian Dong Jing Sun Jian-Jun Li The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease Cardiology Plus cardiovascular events; high-sensitive c-reactive protein; nonobstructive coronary artery disease |
| title | The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease |
| title_full | The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease |
| title_fullStr | The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease |
| title_full_unstemmed | The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease |
| title_short | The relationship between c-reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease |
| title_sort | relationship between c reactive protein and cardiovascular events in patients with obstructive and nonobstructive coronary artery disease |
| topic | cardiovascular events; high-sensitive c-reactive protein; nonobstructive coronary artery disease |
| url | http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2021;volume=6;issue=3;spage=166;epage=173;aulast=Zhang |
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