SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility

SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility

Summary: With the emergence of multiple predominant SARS-CoV-2 variants, it becomes important to have a comprehensive assessment of their viral fitness and transmissibility. Here, we demonstrate that natural temperature differences between the upper (33°C) and lower (37°C) respiratory tract have pro...

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Bibliographic Details
Main Authors: Se-Mi Kim, Eun-Ha Kim, Mark Anthony B. Casel, Young-Il Kim, Rong Sun, Mi-Jeong Kwak, Ji-Seung Yoo, Mina Yu, Kwang-Min Yu, Seung-Gyu Jang, Rare Rollon, Jeong Ho Choi, Juryeon Gil, Kiyoung Eun, Hyunggee Kim, Armin Ensser, Jungwon Hwang, Min-Suk Song, Myung Hee Kim, Jae U. Jung, Young Ki Choi
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723010884

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