Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection
Objective: Urinary tract infection (UTI) is a common cause of morbidity and hospitalisation in the population worldwide. Upper UTI is indolent and causes subclinical acute kidney injury (AKI) resulting in preventable cause of scarring of renal parenchyma. We explored urinary and serum levels of kidn...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Asian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388220300023 |
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| author | Sreerag Kana Rajesh Nachiappa Ganesh Deepanjali Surendran Rajendra G. Kulkarni Ravi Kishore Bobbili Jose Olickal Jeby |
| author_facet | Sreerag Kana Rajesh Nachiappa Ganesh Deepanjali Surendran Rajendra G. Kulkarni Ravi Kishore Bobbili Jose Olickal Jeby |
| author_sort | Sreerag Kana |
| collection | DOAJ |
| description | Objective: Urinary tract infection (UTI) is a common cause of morbidity and hospitalisation in the population worldwide. Upper UTI is indolent and causes subclinical acute kidney injury (AKI) resulting in preventable cause of scarring of renal parenchyma. We explored urinary and serum levels of kidney injury molecule-1 (KIM-1), haematological parameters and quantitative urine microscopy parameters to predict kidney injury. Methods: Neutrophil–lymphocyte ratio (NLR) is obtained by dividing absolute neutrophil count with absolute lymphocyte count. Quantitative urine sediment microscopy was performed and correlated with clinical, biochemical and haematological findings to predict AKI in patients with UTI. Quantitative ELISA was performed for serum and urine levels of KIM-1. Seventy two adult patients with UTI were enrolled, 45 of whom had AKI while 27 were in the non-AKI group. Results: NLR (p=0.005) and renal tubular epithelial cell-granular cast score in quantitative urine microscopy (p=0.008) are strong predictors of AKI in patients with UTI while rest of quantitative urine microscopy parameters and serum and urinary levels of KIM-1 molecule were not found to be useful in prediction of AKI. Conclusion: NLR in haemogram is a novel and useful biomarker for predicting AKI in patients with UTI. |
| first_indexed | 2024-12-18T01:54:16Z |
| format | Article |
| id | doaj.art-5e9648a2bcdc45548b2b667924609b05 |
| institution | Directory Open Access Journal |
| issn | 2214-3882 |
| language | English |
| last_indexed | 2024-12-18T01:54:16Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj.art-5e9648a2bcdc45548b2b667924609b052022-12-21T21:24:57ZengElsevierAsian Journal of Urology2214-38822021-04-0182220226Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infectionSreerag Kana0Rajesh Nachiappa Ganesh1Deepanjali Surendran2Rajendra G. Kulkarni3Ravi Kishore Bobbili4Jose Olickal Jeby5Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India; Corresponding author.Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Immunohaematology and Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaDepartment of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IndiaObjective: Urinary tract infection (UTI) is a common cause of morbidity and hospitalisation in the population worldwide. Upper UTI is indolent and causes subclinical acute kidney injury (AKI) resulting in preventable cause of scarring of renal parenchyma. We explored urinary and serum levels of kidney injury molecule-1 (KIM-1), haematological parameters and quantitative urine microscopy parameters to predict kidney injury. Methods: Neutrophil–lymphocyte ratio (NLR) is obtained by dividing absolute neutrophil count with absolute lymphocyte count. Quantitative urine sediment microscopy was performed and correlated with clinical, biochemical and haematological findings to predict AKI in patients with UTI. Quantitative ELISA was performed for serum and urine levels of KIM-1. Seventy two adult patients with UTI were enrolled, 45 of whom had AKI while 27 were in the non-AKI group. Results: NLR (p=0.005) and renal tubular epithelial cell-granular cast score in quantitative urine microscopy (p=0.008) are strong predictors of AKI in patients with UTI while rest of quantitative urine microscopy parameters and serum and urinary levels of KIM-1 molecule were not found to be useful in prediction of AKI. Conclusion: NLR in haemogram is a novel and useful biomarker for predicting AKI in patients with UTI.http://www.sciencedirect.com/science/article/pii/S2214388220300023Acute kidney injurykidney injury molecule-1Neutrophil–lymphocyte ratioQuantitative urine microscopy scoreUrinary tract infection |
| spellingShingle | Sreerag Kana Rajesh Nachiappa Ganesh Deepanjali Surendran Rajendra G. Kulkarni Ravi Kishore Bobbili Jose Olickal Jeby Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection Asian Journal of Urology Acute kidney injury kidney injury molecule-1 Neutrophil–lymphocyte ratio Quantitative urine microscopy score Urinary tract infection |
| title | Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection |
| title_full | Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection |
| title_fullStr | Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection |
| title_full_unstemmed | Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection |
| title_short | Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection |
| title_sort | urine microscopy and neutrophil lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection |
| topic | Acute kidney injury kidney injury molecule-1 Neutrophil–lymphocyte ratio Quantitative urine microscopy score Urinary tract infection |
| url | http://www.sciencedirect.com/science/article/pii/S2214388220300023 |
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