Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population
Background To investigate oral leukoplakia (OL) and risk of upper gastrointestinal (UGI) cancer deaths in the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort. Methods A total of 3318 subjects with esophageal squamous dysplasia enrolled on 1 May 1985, and were followed up until 30 Septemb...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.13595 |
| _version_ | 1818561739289001984 |
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| author | Huan Yang Su Zhang Jianbing Wang Jinhu Fan Youlin Qiao Philip R. Taylor |
| author_facet | Huan Yang Su Zhang Jianbing Wang Jinhu Fan Youlin Qiao Philip R. Taylor |
| author_sort | Huan Yang |
| collection | DOAJ |
| description | Background To investigate oral leukoplakia (OL) and risk of upper gastrointestinal (UGI) cancer deaths in the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort. Methods A total of 3318 subjects with esophageal squamous dysplasia enrolled on 1 May 1985, and were followed up until 30 September 2015. Participants with OL at baseline were treated as an exposed group, while the remainder was selected as a control group. All subjects were followed monthly and reviewed quarterly by the Linxian Cancer Registry. Cox proportional hazard model was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results During the 30‐year follow‐up, a total of 902 UGI cancer deaths occurred, including 541 esophageal squamous cell carcinoma (ESCC) related, 284 gastric cardia carcinoma (GCC) related, and 77 gastric noncardia carcinoma (GNCC) related deaths. Relative to subjects without OL, the long‐term risk of ESCC mortality in participants with OL increased by 26.1% (HR = 1.26, 95% CI: 1.05–1.52). In the subgroup analyses, adverse effects of OL on ESCC mortality were observed especially in younger subjects (HR = 1.48, 95% CI: 1.11–1.97), females (HR = 1.44, 95% CI: 1.11–1.89), non‐smokers (HR = 1.44, 95% CI: 1.15–1.81), nondrinkers (HR = 1.28, 95% CI: 1.04–1.57), and individuals with a family history of cancer (HR = 1.37, 95% CI: 1.05–1.79). No associations were observed between OL and risk of GCC and GNCC mortality. Conclusions OL may increase the long‐term risk of ESCC mortality, especially in younger subjects, females, nondrinkers, non‐smokers, and subjects with a family cancer history. Future studies are needed to explore the potentially etiological mechanism. |
| first_indexed | 2024-12-14T00:54:45Z |
| format | Article |
| id | doaj.art-5e983028c5374d629efb0efabc119d0e |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-14T00:54:45Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-5e983028c5374d629efb0efabc119d0e2022-12-21T23:23:38ZengWileyThoracic Cancer1759-77061759-77142020-10-0111102804281110.1111/1759-7714.13595Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia populationHuan Yang0Su Zhang1Jianbing Wang2Jinhu Fan3Youlin Qiao4Philip R. Taylor5Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Zhejiang University School of Medicine Hangzhou ChinaDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaMetabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics National Cancer Institute, National Institutes of Health Bethesda Maryland USABackground To investigate oral leukoplakia (OL) and risk of upper gastrointestinal (UGI) cancer deaths in the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort. Methods A total of 3318 subjects with esophageal squamous dysplasia enrolled on 1 May 1985, and were followed up until 30 September 2015. Participants with OL at baseline were treated as an exposed group, while the remainder was selected as a control group. All subjects were followed monthly and reviewed quarterly by the Linxian Cancer Registry. Cox proportional hazard model was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results During the 30‐year follow‐up, a total of 902 UGI cancer deaths occurred, including 541 esophageal squamous cell carcinoma (ESCC) related, 284 gastric cardia carcinoma (GCC) related, and 77 gastric noncardia carcinoma (GNCC) related deaths. Relative to subjects without OL, the long‐term risk of ESCC mortality in participants with OL increased by 26.1% (HR = 1.26, 95% CI: 1.05–1.52). In the subgroup analyses, adverse effects of OL on ESCC mortality were observed especially in younger subjects (HR = 1.48, 95% CI: 1.11–1.97), females (HR = 1.44, 95% CI: 1.11–1.89), non‐smokers (HR = 1.44, 95% CI: 1.15–1.81), nondrinkers (HR = 1.28, 95% CI: 1.04–1.57), and individuals with a family history of cancer (HR = 1.37, 95% CI: 1.05–1.79). No associations were observed between OL and risk of GCC and GNCC mortality. Conclusions OL may increase the long‐term risk of ESCC mortality, especially in younger subjects, females, nondrinkers, non‐smokers, and subjects with a family cancer history. Future studies are needed to explore the potentially etiological mechanism.https://doi.org/10.1111/1759-7714.13595Linxian Dysplasia Nutrition Intervention Trialoral leukoplakiaupper gastrointestinal cancer |
| spellingShingle | Huan Yang Su Zhang Jianbing Wang Jinhu Fan Youlin Qiao Philip R. Taylor Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population Thoracic Cancer Linxian Dysplasia Nutrition Intervention Trial oral leukoplakia upper gastrointestinal cancer |
| title | Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population |
| title_full | Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population |
| title_fullStr | Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population |
| title_full_unstemmed | Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population |
| title_short | Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population |
| title_sort | oral leukoplakia and the long term risk of upper gastrointestinal cancer deaths in the linxian dysplasia population |
| topic | Linxian Dysplasia Nutrition Intervention Trial oral leukoplakia upper gastrointestinal cancer |
| url | https://doi.org/10.1111/1759-7714.13595 |
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