The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells
In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of int...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/2/307 |
| _version_ | 1797477251337420800 |
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| author | Geonhee Han Hyosuk Kim Da Eun Kim Yeonjoo Ahn Joongsoo Kim Ye Ji Jang Kwangmeyung Kim Yoosoo Yang Sun Hwa Kim |
| author_facet | Geonhee Han Hyosuk Kim Da Eun Kim Yeonjoo Ahn Joongsoo Kim Ye Ji Jang Kwangmeyung Kim Yoosoo Yang Sun Hwa Kim |
| author_sort | Geonhee Han |
| collection | DOAJ |
| description | In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of intracellular reactive oxygen species in epidermal keratinocytes. In UV-stimulated melanocytes, colostrum exosomes could also significantly reduce the production of the protective skin-darkening pigment melanin, which may help to reduce the risk of excessive melanin formation causing skin hyperpigmentation disorders. In the human dermal fibroblasts treated with colostrum exosomes, the expression of matrix metalloproteinases was suppressed, whereas increased cell proliferation was accompanied by enhanced production of collagen, a major extracellular matrix component of skin. Taken together, our findings indicate that bovine colostrum-derived exosomes having excellent structural and functional stability offer great potential as natural therapeutic agents to repair UV-irradiated skin aging and damage. |
| first_indexed | 2024-03-09T21:14:56Z |
| format | Article |
| id | doaj.art-5e9bbceae7694e8b932f394ed0c14079 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:14:56Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5e9bbceae7694e8b932f394ed0c140792023-11-23T21:37:06ZengMDPI AGPharmaceutics1999-49232022-01-0114230710.3390/pharmaceutics14020307The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin CellsGeonhee Han0Hyosuk Kim1Da Eun Kim2Yeonjoo Ahn3Joongsoo Kim4Ye Ji Jang5Kwangmeyung Kim6Yoosoo Yang7Sun Hwa Kim8KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seoul 02841, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seoul 02792, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seoul 02792, KoreaDayone Clinic, Seoul 06612, KoreaDayone Clinic, Seoul 06612, KoreaHB Advisors, Seoul 04420, KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seoul 02841, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seoul 02792, KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seoul 02792, KoreaIn this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of intracellular reactive oxygen species in epidermal keratinocytes. In UV-stimulated melanocytes, colostrum exosomes could also significantly reduce the production of the protective skin-darkening pigment melanin, which may help to reduce the risk of excessive melanin formation causing skin hyperpigmentation disorders. In the human dermal fibroblasts treated with colostrum exosomes, the expression of matrix metalloproteinases was suppressed, whereas increased cell proliferation was accompanied by enhanced production of collagen, a major extracellular matrix component of skin. Taken together, our findings indicate that bovine colostrum-derived exosomes having excellent structural and functional stability offer great potential as natural therapeutic agents to repair UV-irradiated skin aging and damage.https://www.mdpi.com/1999-4923/14/2/307bovine colostrumexosomekeratinocytemelanocytefibroblastskin repair |
| spellingShingle | Geonhee Han Hyosuk Kim Da Eun Kim Yeonjoo Ahn Joongsoo Kim Ye Ji Jang Kwangmeyung Kim Yoosoo Yang Sun Hwa Kim The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells Pharmaceutics bovine colostrum exosome keratinocyte melanocyte fibroblast skin repair |
| title | The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells |
| title_full | The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells |
| title_fullStr | The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells |
| title_full_unstemmed | The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells |
| title_short | The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells |
| title_sort | potential of bovine colostrum derived exosomes to repair aged and damaged skin cells |
| topic | bovine colostrum exosome keratinocyte melanocyte fibroblast skin repair |
| url | https://www.mdpi.com/1999-4923/14/2/307 |
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