Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro[S]

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro[S]

Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently charac...

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Bibliographic Details
Main Authors: Eyad Naser, Stephanie Kadow, Fabian Schumacher, Zainelabdeen H. Mohamed, Christian Kappe, Gabriele Hessler, Barbara Pollmeier, Burkhard Kleuser, Christoph Arenz, Katrin Anne Becker, Erich Gulbins, Alexander Carpinteiro
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Journal of Lipid Research
Subjects:
sphingolipids
sphingomyelin
ceramides
lipid metabolism
enzymology
lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520436004

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