Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study
Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.634113/full |
| _version_ | 1819178030640136192 |
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| author | Yao Yao Li Xiao kang Ni Ya feng You Yan hua Qing Pei rong Wang Jia shu Yao Ke ming Ren Lei Zhang Zhi wei Liu Tie jun Song Jinhui Wang Yu-Feng Zang Yue di Shen Wei Chen Wei Chen Wei Chen |
| author_facet | Yao Yao Li Xiao kang Ni Ya feng You Yan hua Qing Pei rong Wang Jia shu Yao Ke ming Ren Lei Zhang Zhi wei Liu Tie jun Song Jinhui Wang Yu-Feng Zang Yue di Shen Wei Chen Wei Chen Wei Chen |
| author_sort | Yao Yao Li |
| collection | DOAJ |
| description | Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs. |
| first_indexed | 2024-12-22T21:36:04Z |
| format | Article |
| id | doaj.art-5e9e10a099054a68a3205171158a736d |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T21:36:04Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-5e9e10a099054a68a3205171158a736d2022-12-21T18:11:45ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-02-011510.3389/fnhum.2021.634113634113Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI StudyYao Yao Li0Xiao kang Ni1Ya feng You2Yan hua Qing3Pei rong Wang4Jia shu Yao5Ke ming Ren6Lei Zhang7Zhi wei Liu8Tie jun Song9Jinhui Wang10Yu-Feng Zang11Yue di Shen12Wei Chen13Wei Chen14Wei Chen15Department of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang Academy of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaClinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaClinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaGuangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, ChinaZhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, ChinaDepartment of Diagnostics, School of Medicine, Hangzhou Normal University, Hangzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, ChinaKey Laboratory of Medical Neurobiology of Zhejiang Province, Hangzhou, ChinaAnxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs.https://www.frontiersin.org/articles/10.3389/fnhum.2021.634113/fullmajor depressive disordermultimodal MRIamygdala subregionanxietyfunctional connectivity |
| spellingShingle | Yao Yao Li Xiao kang Ni Ya feng You Yan hua Qing Pei rong Wang Jia shu Yao Ke ming Ren Lei Zhang Zhi wei Liu Tie jun Song Jinhui Wang Yu-Feng Zang Yue di Shen Wei Chen Wei Chen Wei Chen Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study Frontiers in Human Neuroscience major depressive disorder multimodal MRI amygdala subregion anxiety functional connectivity |
| title | Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study |
| title_full | Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study |
| title_fullStr | Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study |
| title_full_unstemmed | Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study |
| title_short | Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study |
| title_sort | common and specific alterations of amygdala subregions in major depressive disorder with and without anxiety a combined structural and resting state functional mri study |
| topic | major depressive disorder multimodal MRI amygdala subregion anxiety functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.634113/full |
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