Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study
Abstract Background and Aims Dressings containing silver ions are an accepted and common option for wound treatment. However, some wounds fail to heal at the desired rate despite optimal management. The aim of the study was to examine the effect of copper dressings in noninfected wounds. Methods The...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1816 |
| _version_ | 1797331686114983936 |
|---|---|
| author | Oxana Gorel Mozna Hamuda Ilana Feldman Irit Kucyn‐Gabovich |
| author_facet | Oxana Gorel Mozna Hamuda Ilana Feldman Irit Kucyn‐Gabovich |
| author_sort | Oxana Gorel |
| collection | DOAJ |
| description | Abstract Background and Aims Dressings containing silver ions are an accepted and common option for wound treatment. However, some wounds fail to heal at the desired rate despite optimal management. The aim of the study was to examine the effect of copper dressings in noninfected wounds. Methods The study included 20 patients aged 18–85 years with 2–30 cm2 noninfected wounds treated for 17–41 days with silver wound dressings that failed to reduce by >50% the wound size, who were then treated with copper dressings. Ten patients were diabetics, 10 suffered from hypertension, and six suffered from peripheral vascular disease (PVD). Two patients suffered from two wounds. Most were amputation wounds below the knee. Results Five patients dropped out from the study due to complications not related to the wound. The mean period of silver and copper dressings treatment was 25.6 and 29.6 days, respectively (p = 0.25; t test). None of the wounds became infected. Comparing a period of 25 days, during the copper dressings treatment, the mean wound area reduction was ~2.4 times higher than during the silver dressing treatment, 87.35 ± 22.4% versus 37.02 ± 25.11% (mean ± SD; p < 0.001; paired t test), respectively. The average decline during the silver and copper treatments were 1.2% and 2.14% per day (p = 0.002; multiple regression analysis), respectively. Conclusions The enhanced wound healing process observed with the copper dressings may be explained by the integral role of copper throughout all physiological skin repair processes. Silver in contrast has no physiological role in wound healing. The results of our study confirm case reports showing enhanced wound healing of hard‐to‐heal wounds with copper dressings, both of infected and noninfected wounds. Taken together, the results of the current study support the hypothesis that the application of copper dressings in situ for noninfected wounds results in the stimulation of the wound healing processes, as opposed to silver dressings. |
| first_indexed | 2024-03-08T07:38:02Z |
| format | Article |
| id | doaj.art-5ea04e55185c48dab964b223f03cc571 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-08T07:38:02Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-5ea04e55185c48dab964b223f03cc5712024-02-02T18:04:59ZengWileyHealth Science Reports2398-88352024-01-0171n/an/a10.1002/hsr2.1816Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment studyOxana Gorel0Mozna Hamuda1Ilana Feldman2Irit Kucyn‐Gabovich3Loewenstein Rehabilitation Center Ra'anana IsraelLoewenstein Rehabilitation Center Ra'anana IsraelLoewenstein Rehabilitation Center Ra'anana IsraelLoewenstein Rehabilitation Center Ra'anana IsraelAbstract Background and Aims Dressings containing silver ions are an accepted and common option for wound treatment. However, some wounds fail to heal at the desired rate despite optimal management. The aim of the study was to examine the effect of copper dressings in noninfected wounds. Methods The study included 20 patients aged 18–85 years with 2–30 cm2 noninfected wounds treated for 17–41 days with silver wound dressings that failed to reduce by >50% the wound size, who were then treated with copper dressings. Ten patients were diabetics, 10 suffered from hypertension, and six suffered from peripheral vascular disease (PVD). Two patients suffered from two wounds. Most were amputation wounds below the knee. Results Five patients dropped out from the study due to complications not related to the wound. The mean period of silver and copper dressings treatment was 25.6 and 29.6 days, respectively (p = 0.25; t test). None of the wounds became infected. Comparing a period of 25 days, during the copper dressings treatment, the mean wound area reduction was ~2.4 times higher than during the silver dressing treatment, 87.35 ± 22.4% versus 37.02 ± 25.11% (mean ± SD; p < 0.001; paired t test), respectively. The average decline during the silver and copper treatments were 1.2% and 2.14% per day (p = 0.002; multiple regression analysis), respectively. Conclusions The enhanced wound healing process observed with the copper dressings may be explained by the integral role of copper throughout all physiological skin repair processes. Silver in contrast has no physiological role in wound healing. The results of our study confirm case reports showing enhanced wound healing of hard‐to‐heal wounds with copper dressings, both of infected and noninfected wounds. Taken together, the results of the current study support the hypothesis that the application of copper dressings in situ for noninfected wounds results in the stimulation of the wound healing processes, as opposed to silver dressings.https://doi.org/10.1002/hsr2.1816amputationsnoninfected woundssilver dressingcopper dressingsurgery woundswound management |
| spellingShingle | Oxana Gorel Mozna Hamuda Ilana Feldman Irit Kucyn‐Gabovich Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study Health Science Reports amputations noninfected wounds silver dressing copper dressing surgery wounds wound management |
| title | Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study |
| title_full | Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study |
| title_fullStr | Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study |
| title_full_unstemmed | Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study |
| title_short | Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study |
| title_sort | enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings prospective single arm treatment study |
| topic | amputations noninfected wounds silver dressing copper dressing surgery wounds wound management |
| url | https://doi.org/10.1002/hsr2.1816 |
| work_keys_str_mv | AT oxanagorel enhancedhealingofwoundsthatrespondedpoorlytosilverdressingbycopperwounddressingsprospectivesinglearmtreatmentstudy AT moznahamuda enhancedhealingofwoundsthatrespondedpoorlytosilverdressingbycopperwounddressingsprospectivesinglearmtreatmentstudy AT ilanafeldman enhancedhealingofwoundsthatrespondedpoorlytosilverdressingbycopperwounddressingsprospectivesinglearmtreatmentstudy AT iritkucyngabovich enhancedhealingofwoundsthatrespondedpoorlytosilverdressingbycopperwounddressingsprospectivesinglearmtreatmentstudy |