The antioxidant defense system at early stages of chronic cerebrovascular pathology
A total of 109 patients with initial manifestations of chronic cerebrovascularpathology (CCVP) and uncomplicated hypertension(degree 12) and 30 healthy individuals (control group) wereexamined. The patients underwent comprehensive clinical andlaboratory testing. Lipid peroxidation (LPO) was assessed...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/158/77 |
| _version_ | 1818230671181611008 |
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| author | E. V. Gnedovskaya A. A. Logvinenko O. S. Andreeva M. A. Kravchenko G. V. Gornostaeva T. N. Fedorova E. V. Oshchepkova Yu. Ya. Varakin |
| author_facet | E. V. Gnedovskaya A. A. Logvinenko O. S. Andreeva M. A. Kravchenko G. V. Gornostaeva T. N. Fedorova E. V. Oshchepkova Yu. Ya. Varakin |
| author_sort | E. V. Gnedovskaya |
| collection | DOAJ |
| description | A total of 109 patients with initial manifestations of chronic cerebrovascularpathology (CCVP) and uncomplicated hypertension(degree 12) and 30 healthy individuals (control group) wereexamined. The patients underwent comprehensive clinical andlaboratory testing. Lipid peroxidation (LPO) was assessed usingchemiluminescence of LDLP induced by Fe2+ ions. Reduced antioxidantactivity was revealed in 94.2% of patients with CCVPassociated with hypertension as compared to healthy individuals;individual LPO components were enhanced. Dyscirculatoryencephalopathy in patients with hypertension was preceded bya period of early or initial manifestations of cerebrovascular disorderswith activation of free radical oxidation and depletion ofthe endogenous antioxidant system being comparable in terms oftheir severity. Enhancement of oxidation processes was observedin patients presenting with severe and frequent hypertensive urgencies,multiple microfocal cerebral lesions, dyslipoproteinemia,and increased red blood cell aggregation at the early stagesof chronic cerebrovascular pathology. |
| first_indexed | 2024-12-12T10:38:12Z |
| format | Article |
| id | doaj.art-5ea114e57e7d41328d9d1126e23c6a8a |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T10:38:12Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-5ea114e57e7d41328d9d1126e23c6a8a2022-12-22T00:27:09ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0191202410.17816/psaic158139The antioxidant defense system at early stages of chronic cerebrovascular pathologyE. V. Gnedovskaya0A. A. Logvinenko1O. S. Andreeva2M. A. Kravchenko3G. V. Gornostaeva4T. N. Fedorova5E. V. Oshchepkova6Yu. Ya. Varakin7Research Center of Neurology (Moscow)Research Center of Neurology (Moscow)Research Center of Neurology (Moscow)Research Center of Neurology (Moscow)Research Center of Neurology (Moscow)Research Center of Neurology (Moscow)Research Center of Neurology (Moscow)Research Center of Neurology (Moscow)A total of 109 patients with initial manifestations of chronic cerebrovascularpathology (CCVP) and uncomplicated hypertension(degree 12) and 30 healthy individuals (control group) wereexamined. The patients underwent comprehensive clinical andlaboratory testing. Lipid peroxidation (LPO) was assessed usingchemiluminescence of LDLP induced by Fe2+ ions. Reduced antioxidantactivity was revealed in 94.2% of patients with CCVPassociated with hypertension as compared to healthy individuals;individual LPO components were enhanced. Dyscirculatoryencephalopathy in patients with hypertension was preceded bya period of early or initial manifestations of cerebrovascular disorderswith activation of free radical oxidation and depletion ofthe endogenous antioxidant system being comparable in terms oftheir severity. Enhancement of oxidation processes was observedin patients presenting with severe and frequent hypertensive urgencies,multiple microfocal cerebral lesions, dyslipoproteinemia,and increased red blood cell aggregation at the early stagesof chronic cerebrovascular pathology.https://annaly-nevrologii.com/journal/pathID/article/viewFile/158/77chronic cerebrovascular pathologylipid peroxidationchemiluminescencehypertension |
| spellingShingle | E. V. Gnedovskaya A. A. Logvinenko O. S. Andreeva M. A. Kravchenko G. V. Gornostaeva T. N. Fedorova E. V. Oshchepkova Yu. Ya. Varakin The antioxidant defense system at early stages of chronic cerebrovascular pathology Анналы клинической и экспериментальной неврологии chronic cerebrovascular pathology lipid peroxidation chemiluminescence hypertension |
| title | The antioxidant defense system at early stages of chronic cerebrovascular pathology |
| title_full | The antioxidant defense system at early stages of chronic cerebrovascular pathology |
| title_fullStr | The antioxidant defense system at early stages of chronic cerebrovascular pathology |
| title_full_unstemmed | The antioxidant defense system at early stages of chronic cerebrovascular pathology |
| title_short | The antioxidant defense system at early stages of chronic cerebrovascular pathology |
| title_sort | antioxidant defense system at early stages of chronic cerebrovascular pathology |
| topic | chronic cerebrovascular pathology lipid peroxidation chemiluminescence hypertension |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/158/77 |
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