Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease
Background Oxidative stress modulates insulin resistant-related atherogenic dyslipidemia: hypertriglyceridemia (HTG) and low high-density lipoprotein cholesterol (HDL-C) level. Gene polymorphisms in superoxide dismutase (SOD2 and SOD3), glutathione peroxidase-3 (GPX3), and glutathione S-transferase...
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PeerJ Inc.
2019-08-01
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| Online Access: | https://peerj.com/articles/7407.pdf |
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| author | Nisa Decharatchakul Chatri Settasatian Nongnuch Settasatian Nantarat Komanasin Upa Kukongviriyapan Phongsak Intharaphet Vichai Senthong |
| author_facet | Nisa Decharatchakul Chatri Settasatian Nongnuch Settasatian Nantarat Komanasin Upa Kukongviriyapan Phongsak Intharaphet Vichai Senthong |
| author_sort | Nisa Decharatchakul |
| collection | DOAJ |
| description | Background Oxidative stress modulates insulin resistant-related atherogenic dyslipidemia: hypertriglyceridemia (HTG) and low high-density lipoprotein cholesterol (HDL-C) level. Gene polymorphisms in superoxide dismutase (SOD2 and SOD3), glutathione peroxidase-3 (GPX3), and glutathione S-transferase theta-1 (GSTT1) may enable oxidative stress-related lipid abnormalities and severity of coronary atherosclerosis. The present study investigated the associations of antioxidant-related gene polymorphisms with atherogenic dyslipidemia and atherosclerotic severity in subjects with high risk of coronary artery disease (CAD). Methods Study population comprises of 396 subjects with high risk of CAD. Gene polymorphisms: SOD2 rs4880, SOD3 rs2536512 and rs2855262, GPX rs3828599, and GSTT1 (deletion) were evaluated the associations with HTG, low HDL-C, high TG/HDL-C ratio, and severity of coronary atherosclerosis. Results SOD2 rs4880-CC, SOD3 rs2536512-AA, rs2855262-CC, and GPX3 rs3828599-AA, but not GSTT1-/- individually increased risk of HTG combined with low HDL-C level. With a combination of five risk-genotypes as a genetic risk score (GRS), GRS ≥ 6 increased risks of low HDL-C, high TG/HDL-C ratio, and HTG combined with low HDL-C, comparing with GRS 0–2 [respective adjusted ORs (95% CI) = 2.70 (1.24–5.85), 3.11 (1.55–6.23), and 5.73 (2.22–14.77)]. Gene polymorphisms, though, were not directly associated with severity of coronary atherosclerosis; high TG/HDL-C ratio was associated with coronary atherosclerotic severity [OR = 2.26 (95% CI [1.17–4.34])]. Conclusion Combined polymorphisms in antioxidant-related genes increased the risk of dyslipidemia related to atherosclerotic severity, suggesting the combined antioxidant-related gene polymorphisms as predictor of atherogenic dyslipidemia. |
| first_indexed | 2024-03-09T06:39:15Z |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:39:15Z |
| publishDate | 2019-08-01 |
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| spelling | doaj.art-5ea7602592ee4055b47d4f36ff58bcf42023-12-03T10:54:09ZengPeerJ Inc.PeerJ2167-83592019-08-017e740710.7717/peerj.7407Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery diseaseNisa Decharatchakul0Chatri Settasatian1Nongnuch Settasatian2Nantarat Komanasin3Upa Kukongviriyapan4Phongsak Intharaphet5Vichai Senthong6Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, ThailandCardiovascular Research Group, Khon Kaen University, Khon Kaen, ThailandCardiovascular Research Group, Khon Kaen University, Khon Kaen, ThailandCardiovascular Research Group, Khon Kaen University, Khon Kaen, ThailandCardiovascular Research Group, Khon Kaen University, Khon Kaen, ThailandCardiovascular Research Group, Khon Kaen University, Khon Kaen, ThailandCardiovascular Research Group, Khon Kaen University, Khon Kaen, ThailandBackground Oxidative stress modulates insulin resistant-related atherogenic dyslipidemia: hypertriglyceridemia (HTG) and low high-density lipoprotein cholesterol (HDL-C) level. Gene polymorphisms in superoxide dismutase (SOD2 and SOD3), glutathione peroxidase-3 (GPX3), and glutathione S-transferase theta-1 (GSTT1) may enable oxidative stress-related lipid abnormalities and severity of coronary atherosclerosis. The present study investigated the associations of antioxidant-related gene polymorphisms with atherogenic dyslipidemia and atherosclerotic severity in subjects with high risk of coronary artery disease (CAD). Methods Study population comprises of 396 subjects with high risk of CAD. Gene polymorphisms: SOD2 rs4880, SOD3 rs2536512 and rs2855262, GPX rs3828599, and GSTT1 (deletion) were evaluated the associations with HTG, low HDL-C, high TG/HDL-C ratio, and severity of coronary atherosclerosis. Results SOD2 rs4880-CC, SOD3 rs2536512-AA, rs2855262-CC, and GPX3 rs3828599-AA, but not GSTT1-/- individually increased risk of HTG combined with low HDL-C level. With a combination of five risk-genotypes as a genetic risk score (GRS), GRS ≥ 6 increased risks of low HDL-C, high TG/HDL-C ratio, and HTG combined with low HDL-C, comparing with GRS 0–2 [respective adjusted ORs (95% CI) = 2.70 (1.24–5.85), 3.11 (1.55–6.23), and 5.73 (2.22–14.77)]. Gene polymorphisms, though, were not directly associated with severity of coronary atherosclerosis; high TG/HDL-C ratio was associated with coronary atherosclerotic severity [OR = 2.26 (95% CI [1.17–4.34])]. Conclusion Combined polymorphisms in antioxidant-related genes increased the risk of dyslipidemia related to atherosclerotic severity, suggesting the combined antioxidant-related gene polymorphisms as predictor of atherogenic dyslipidemia.https://peerj.com/articles/7407.pdfAntioxidantGlutathione peroxidaseSuperoxide dismutaseGlutathioneS-transferaseAtherosclerosisOxidative stress |
| spellingShingle | Nisa Decharatchakul Chatri Settasatian Nongnuch Settasatian Nantarat Komanasin Upa Kukongviriyapan Phongsak Intharaphet Vichai Senthong Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease PeerJ Antioxidant Glutathione peroxidase Superoxide dismutase GlutathioneS-transferase Atherosclerosis Oxidative stress |
| title | Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease |
| title_full | Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease |
| title_fullStr | Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease |
| title_full_unstemmed | Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease |
| title_short | Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease |
| title_sort | association of genetic polymorphisms in sod2 sod3 gpx3 and gstt1 with hypertriglyceridemia and low hdl c level in subjects with high risk of coronary artery disease |
| topic | Antioxidant Glutathione peroxidase Superoxide dismutase GlutathioneS-transferase Atherosclerosis Oxidative stress |
| url | https://peerj.com/articles/7407.pdf |
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