Continuous Developmental and Early Life Trichloroethylene Exposure Promoted DNA Methylation Alterations in Polycomb Protein Binding Sites in Effector/Memory CD4+ T Cells

Continuous Developmental and Early Life Trichloroethylene Exposure Promoted DNA Methylation Alterations in Polycomb Protein Binding Sites in Effector/Memory CD4+ T Cells

Trichloroethylene (TCE) is an industrial solvent and drinking water pollutant associated with CD4+ T cell-mediated autoimmunity. In our mouse model, discontinuation of TCE exposure during adulthood after developmental exposure did not prevent immunotoxicity. To determine whether persistent effects w...

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Bibliographic Details
Main Authors: Stephanie D. Byrum, Charity L. Washam, John D. Patterson, Kanan K. Vyas, Kathleen M. Gilbert, Sarah J. Blossom
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
polycomb
trichloroethylene
CD4+ T cell
DNA methylation
developmental exposure
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02016/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02016/full

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