Differential expression of programmed death 1 (PD-1) on various immune cells and its role in human leprosy

Differential expression of programmed death 1 (PD-1) on various immune cells and its role in human leprosy

Leprosy is a chronic bacterial disease caused by Mycobacterium leprae. Leprosy patients have been found to have defects in T cells activation, which is critical to the clearance of the bacilli. Treg cell suppression is mediated by inhibitory cytokines such as IL10, IL-35 and TGF-β and its frequency...

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Bibliographic Details
Main Authors: Mohammad Tarique, Huma Naz, Mohd Suhail, Ali Turan, Chaman Saini, Naoshad Muhammad, Hari Shankar, Torki A. Zughaibi, Tabish H. Khan, Neena Khanna, Alpana Sharma
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
leprosy
T cells
Tregs
PD-1
IL-10
T cell anergy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1138145/full

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