Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery
Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1−1000 µm size range, serve as multiunit drug delivery systems with w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Scientia Pharmaceutica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-0532/87/3/20 |
| _version_ | 1811301252130144256 |
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| author | Miléna Lengyel Nikolett Kállai-Szabó Vince Antal András József Laki István Antal |
| author_facet | Miléna Lengyel Nikolett Kállai-Szabó Vince Antal András József Laki István Antal |
| author_sort | Miléna Lengyel |
| collection | DOAJ |
| description | Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1−1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail. |
| first_indexed | 2024-04-13T07:05:27Z |
| format | Article |
| id | doaj.art-5eaf7316d13542e4a65790b0a74bf43c |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-13T07:05:27Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-5eaf7316d13542e4a65790b0a74bf43c2022-12-22T02:57:00ZengMDPI AGScientia Pharmaceutica2218-05322019-08-018732010.3390/scipharm87030020scipharm87030020Microparticles, Microspheres, and Microcapsules for Advanced Drug DeliveryMiléna Lengyel0Nikolett Kállai-Szabó1Vince Antal2András József Laki3István Antal4Department of Pharmaceutics, Semmelweis University, Hőgyes E. str 7, 1092 Budapest, HungaryDepartment of Pharmaceutics, Semmelweis University, Hőgyes E. str 7, 1092 Budapest, HungaryDepartment of Pharmaceutics, Semmelweis University, Hőgyes E. str 7, 1092 Budapest, HungaryPázmány Péter Catholic University, Faculty of Information Technology and Bionics, Práter str 50/A, 1083 Budapest, HungaryDepartment of Pharmaceutics, Semmelweis University, Hőgyes E. str 7, 1092 Budapest, HungaryMicroparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1−1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.https://www.mdpi.com/2218-0532/87/3/20multiparticulate formulationspolymer excipientsprocesses for microparticles in therapystructure and drug releasemicrofluidicsmicrobubblesmicrosponge |
| spellingShingle | Miléna Lengyel Nikolett Kállai-Szabó Vince Antal András József Laki István Antal Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery Scientia Pharmaceutica multiparticulate formulations polymer excipients processes for microparticles in therapy structure and drug release microfluidics microbubbles microsponge |
| title | Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery |
| title_full | Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery |
| title_fullStr | Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery |
| title_full_unstemmed | Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery |
| title_short | Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery |
| title_sort | microparticles microspheres and microcapsules for advanced drug delivery |
| topic | multiparticulate formulations polymer excipients processes for microparticles in therapy structure and drug release microfluidics microbubbles microsponge |
| url | https://www.mdpi.com/2218-0532/87/3/20 |
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