Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response
Abstract: The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in a...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100009&lng=en&tlng=en |
| _version_ | 1818265192635564032 |
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| author | Adriano Queiroz Lee W. Riley |
| author_facet | Adriano Queiroz Lee W. Riley |
| author_sort | Adriano Queiroz |
| collection | DOAJ |
| description | Abstract: The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in an infected human host. Accumulating evidence suggests that M. tuberculosis remodels the lipid composition of the cell wall as an adaptive mechanism against host-imposed stress. Some of these lipid species (trehalose dimycolate, diacylated sulphoglycolipid, and mannan-based lipoglycans) trigger an immunopathologic response, whereas others (phthiocerol dimycocerosate, mycolic acids, sulpholipid-1, and di-and polyacyltrehalose) appear to dampen the immune responses. These lipids appear to be coordinately expressed in the cell wall of M. tuberculosis during different phases of infection, ultimately determining the clinical fate of the infection. This review summarizes the current state of knowledge on the metabolism, transport, and homeostatic or immunostatic regulation of the cell wall lipids, and their orchestrated interaction with host immune responses that results in bacterial clearance, persistence, or tuberculosis. |
| first_indexed | 2024-12-12T19:46:54Z |
| format | Article |
| id | doaj.art-5eafe434d6bf4c83a64fe00aa6e3d5c7 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T19:46:54Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-5eafe434d6bf4c83a64fe00aa6e3d5c72022-12-22T00:14:03ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984950191810.1590/0037-8682-0230-2016S0037-86822017000100009Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune responseAdriano QueirozLee W. RileyAbstract: The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in an infected human host. Accumulating evidence suggests that M. tuberculosis remodels the lipid composition of the cell wall as an adaptive mechanism against host-imposed stress. Some of these lipid species (trehalose dimycolate, diacylated sulphoglycolipid, and mannan-based lipoglycans) trigger an immunopathologic response, whereas others (phthiocerol dimycocerosate, mycolic acids, sulpholipid-1, and di-and polyacyltrehalose) appear to dampen the immune responses. These lipids appear to be coordinately expressed in the cell wall of M. tuberculosis during different phases of infection, ultimately determining the clinical fate of the infection. This review summarizes the current state of knowledge on the metabolism, transport, and homeostatic or immunostatic regulation of the cell wall lipids, and their orchestrated interaction with host immune responses that results in bacterial clearance, persistence, or tuberculosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100009&lng=en&tlng=enMycobacterium tuberculosisLipidsImmune response |
| spellingShingle | Adriano Queiroz Lee W. Riley Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response Revista da Sociedade Brasileira de Medicina Tropical Mycobacterium tuberculosis Lipids Immune response |
| title | Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response |
| title_full | Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response |
| title_fullStr | Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response |
| title_full_unstemmed | Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response |
| title_short | Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response |
| title_sort | bacterial immunostat mycobacterium tuberculosis lipids and their role in the host immune response |
| topic | Mycobacterium tuberculosis Lipids Immune response |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100009&lng=en&tlng=en |
| work_keys_str_mv | AT adrianoqueiroz bacterialimmunostatmycobacteriumtuberculosislipidsandtheirroleinthehostimmuneresponse AT leewriley bacterialimmunostatmycobacteriumtuberculosislipidsandtheirroleinthehostimmuneresponse |